HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: RBP56 (Q92804)
TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56)
Gene: TAF15

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31527615, unassigned1953
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 592
+	Hs
		369431 ESR1_HUMAN (1-595): 0: 599: 100.00		EWS_HUMAN (4-383): 3.73e-35: 142: 32.96
+	Hs
		369097 ESR1_HUMAN (1-595): 0: 599: 100.00		FUS_HUMAN (8-381): 2.72e-32: 132: 39.28
+	Hs
		370772 ESR1_HUMAN (1-595): 0: 599: 100.00		RBMX2_HUMAN (227-440): 6.24e-28: 116: 19.36
+	Hs
		369584 ESR1_HUMAN (1-595): 0: 599: 100.00		EIF3A_HUMAN (314-591): 5.41e-22: 103: 18.21
+	Hs
		1269278 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		RBP56_HUMAN (1-394): 3.45e-37: 148: 100.00
+	Hs
		212165 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		HTSF1_HUMAN (113-325): 5.58e-31: 130: 18.06
+	Hs
		1269993 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		RBMX2_HUMAN (227-440): 6.24e-28: 116: 19.36
+	Hs
		587128 RXRA_HUMAN (65-551): 4.55e-127: 383: 26.47		FUS_HUMAN (8-381): 2.72e-32: 132: 39.28
+	Hs
		1049612 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		EIF3A_HUMAN (314-591): 5.41e-22: 103: 18.21
+	Hs
		611479 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		RBP56_HUMAN (1-394): 3.45e-37: 148: 100.00
+	Mm
		1142642 ERR2_MOUSE (92-547): 6.98e-113: 345: 34.42		EWS_MOUSE (4-383): 9.82e-32: 132: 33.26
+	Mm
		509287 RARA_MOUSE (81-545): 8.36e-104: 323: 22.37		EIF3A_MOUSE (330-590): 1.61e-33: 138: 23.27
+	Mm
		509319 RARA_MOUSE (81-545): 8.36e-104: 323: 22.37		EWS_MOUSE (4-383): 9.82e-32: 132: 33.26
+	Mm
		509294 RARA_MOUSE (81-545): 8.36e-104: 323: 22.37		FUS_MOUSE (8-381): 1.02e-31: 131: 38.30
+	Hs
		510005 ERR1_HUMAN (123-547): 6.94e-103: 319: 34.04		FUS_HUMAN (8-381): 2.72e-32: 132: 39.28
+	Hs
		659716 RXRB_HUMAN (144-549): 1.9e-111: 345: 27.64		EIF3A_HUMAN (314-591): 5.41e-22: 103: 18.21
+	Hs
		795597 NR4A2_HUMAN (87-544): 1.09e-105: 332: 24.52		EIF3A_HUMAN (314-591): 5.41e-22: 103: 18.21
+	Hs
		487638 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		RBP56_HUMAN (1-394): 3.45e-37: 148: 100.00
+	Hs
		487184 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		FUS_HUMAN (8-381): 2.72e-32: 132: 39.28