HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: SIG10 (Q96LC7)
Sialic acid-binding Ig-like lectin 10 (Siglec-10) (Siglec-like protein 2)
Gene: SIGLEC10

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 697
+	Hs
		370124 ESR1_HUMAN (1-595): 0: 599: 100.00		PXDN_HUMAN (345-689): 1.61e-32: 137: 11.94
+	Hs
		178068 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		NCAM2_HUMAN (49-680): 9.14e-77: 265: 13.90
+	Hs
		370105 ESR1_HUMAN (1-595): 0: 599: 100.00		TITIN_HUMAN (358-443): 2.47e-09: 63.2: 15.96
+	Mm
		587103 ESR1_MOUSE (1-595): 0: 570: 88.98		CNTN2_MOUSE (452-684): 6.94e-11: 67.8: 8.43
+	Hs
		611509 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		ROBO2_HUMAN (7-666): 4.13e-65: 236: 12.22
+	Hs
		874396 NR1H2_HUMAN (103-548): 4.02e-105: 326: 21.26		ROBO2_HUMAN (7-666): 4.13e-65: 236: 12.22
+	Hs
		1268524 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PXDN_HUMAN (345-689): 1.61e-32: 137: 11.94
+	Hs
		1264774 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TITIN_HUMAN (358-443): 2.47e-09: 63.2: 15.96
+	Hs
		957553 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PGBM_HUMAN (442-610): 3.17e-09: 62.8: 11.77
+	Hs
		377539 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		TITIN_HUMAN (358-443): 2.47e-09: 63.2: 15.96