HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: SRPK1 (Q96SB4)
SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1)
Gene: SRPK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	31527615, 33731348, 21182205, unassigned1953
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 655
+	Hs
		369378 ESR1_HUMAN (1-595): 0: 599: 100.00		SRPK2_HUMAN (48-655): 9.43e-136: 415: 57.97
+	Hs
		1269424 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SRPK1_HUMAN (1-655): 5.68e-157: 468: 94.64
+	Hs
		369662 ESR1_HUMAN (1-595): 0: 599: 100.00		KS6A1_HUMAN (1-359): 2.84e-81: 273: 14.32
+	Hs
		369218 ESR1_HUMAN (1-595): 0: 599: 100.00		KS6A3_HUMAN (1-353): 1.92e-78: 266: 13.83
+	Hs
		914671 ERR3_HUMAN (91-547): 2.27e-116: 355: 33.77		SRPK1_HUMAN (1-655): 5.68e-157: 468: 94.64
+	Hs
		942851 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		SRPK2_HUMAN (48-655): 9.43e-136: 415: 57.97
+	Hs
		369006 ESR1_HUMAN (1-595): 0: 599: 100.00		CDK2_HUMAN (414-653): 1.01e-65: 219: 19.43
+	Hs
		370471 ESR1_HUMAN (1-595): 0: 599: 100.00		CLK4_HUMAN (436-654): 5.51e-63: 218: 23.89
+	Hs
		369195 ESR1_HUMAN (1-595): 0: 599: 100.00		CLK3_HUMAN (484-653): 1.02e-60: 216: 28.65
+	Hs
		369024 ESR1_HUMAN (1-595): 0: 599: 100.00		MARK3_HUMAN (409-655): 3.06e-47: 179: 12.65
+	Hs
		369888 ESR1_HUMAN (1-595): 0: 599: 100.00		MARK2_HUMAN (409-654): 1.03e-46: 178: 12.70
+	Hs
		587205 RXRA_HUMAN (65-551): 4.55e-127: 383: 26.47		KS6A6_HUMAN (1-349): 8.64e-77: 261: 15.01
+	Hs
		834090 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		CLK3_HUMAN (484-653): 1.02e-60: 216: 28.65
+	Hs
		611521 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		KS6A6_HUMAN (1-349): 8.64e-77: 261: 15.01
+	Hs
		647937 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MARK3_HUMAN (409-655): 3.06e-47: 179: 12.65
+	Hs
		1183083 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		MARK2_HUMAN (409-654): 1.03e-46: 178: 12.70
+	Hs
		487459 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		KS6A1_HUMAN (1-359): 2.84e-81: 273: 14.32
+	Hs
		414440 PRGR_HUMAN (183-508): 6.92e-44: 170: 32.14		CDK2_HUMAN (414-653): 1.01e-65: 219: 19.43