HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: TCAB1 (Q9BUR4)
Telomerase Cajal body protein 1 (WD repeat-containing protein 79) (WD40 repeat-containing protein antisense to TP53 gene) (WRAP53beta)
Gene: WRAP53

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31527615, unassigned1953
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 548
+	Hs
		369669 ESR1_HUMAN (1-595): 0: 599: 100.00		TAF5_HUMAN (263-535): 4.71e-59: 211: 15.44
+	Hs
		370377 ESR1_HUMAN (1-595): 0: 599: 100.00		TBL1R_HUMAN (274-548): 1.41e-51: 185: 15.41
+	Hs
		370309 ESR1_HUMAN (1-595): 0: 599: 100.00		TBL1Y_HUMAN (274-548): 1.31e-49: 180: 15.75
+	Hs
		267731 ESR1_HUMAN (1-595): 0: 599: 100.00		TAF5L_HUMAN (234-534): 1.86e-43: 164: 13.92
+	Hs
		196938 ESR1_HUMAN (1-595): 0: 599: 100.00		PRP4_HUMAN (305-548): 2.59e-40: 155: 14.74
+	Hs
		369932 ESR1_HUMAN (1-595): 0: 599: 100.00		WDR5B_HUMAN (361-541): 2.58e-41: 153: 12.16
+	Hs
		1269501 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TCAB1_HUMAN (1-548): 2.69e-107: 333: 98.37
+	Hs
		370470 ESR1_HUMAN (1-595): 0: 599: 100.00		GBB4_HUMAN (103-353): 1.08e-34: 135: 14.63
+	Hs
		369344 ESR1_HUMAN (1-595): 0: 599: 100.00		GBB2_HUMAN (341-546): 6.74e-33: 130: 12.62
+	Hs
		369362 ESR1_HUMAN (1-595): 0: 599: 100.00		RACK1_HUMAN (259-482): 1.47e-23: 103: 16.52
+	Hs
		369305 ESR1_HUMAN (1-595): 0: 599: 100.00		WDR5_HUMAN (455-548): 1.44e-18: 88.9: 9.57
+	Hs
		1074801 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TAF5_HUMAN (263-535): 4.71e-59: 211: 15.44
+	Hs
		1269548 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TBL1R_HUMAN (274-548): 1.41e-51: 185: 15.41
+	Hs
		1269467 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TBL1Y_HUMAN (274-548): 1.31e-49: 180: 15.75
+	Hs
		267782 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		TAF5L_HUMAN (234-534): 1.86e-43: 164: 13.92
+	Hs
		197064 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PRP4_HUMAN (305-548): 2.59e-40: 155: 14.74
+	Hs
		560885 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		GBB3_HUMAN (103-353): 4.07e-35: 136: 14.23
+	Hs
		921671 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		GBB2_HUMAN (341-546): 6.74e-33: 130: 12.62
+	Hs
		929598 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		RACK1_HUMAN (259-482): 1.47e-23: 103: 16.52
+	Hs
		903403 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		WDR5_HUMAN (455-548): 1.44e-18: 88.9: 9.57