HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: YTDC2 (Q9H6S0)
3'-5' RNA helicase YTHDC2 (EC 3.6.4.13) (YTH domain-containing protein 2) (hYTHDC2)
Gene: YTHDC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.50	0.521

Property	Details
Experiments	31527615, unassigned1953
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 1430
+	Hs
		1269620 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		YTDC2_HUMAN (1-1430): 0: 1502: 100.00
+	Hs
		369604 ESR1_HUMAN (1-595): 0: 599: 100.00		DHX8_HUMAN (25-482): 1.24e-127: 428: 22.61
+	Hs
		370123 ESR1_HUMAN (1-595): 0: 599: 100.00		PRP16_HUMAN (25-482): 4.04e-118: 402: 22.57
+	Hs
		195307 ESR1_HUMAN (1-595): 0: 599: 100.00		DHX15_HUMAN (164-482): 6.33e-112: 374: 26.65
+	Hs
		370421 ESR1_HUMAN (1-595): 0: 599: 100.00		DHX36_HUMAN (71-521): 4.15e-100: 346: 27.63
+	Hs
		369959 ESR1_HUMAN (1-595): 0: 599: 100.00		DHX40_HUMAN (191-481): 5.27e-100: 340: 25.40
+	Hs
		370441 ESR1_HUMAN (1-595): 0: 599: 100.00		DHX33_HUMAN (140-476): 6.02e-99: 335: 25.57
+	Hs
		369904 ESR1_HUMAN (1-595): 0: 599: 100.00		DHX29_HUMAN (139-425): 6.43e-94: 334: 39.32
+	Hs
		369477 ESR1_HUMAN (1-595): 0: 599: 100.00		DHX9_HUMAN (119-458): 1.05e-90: 323: 32.77
+	Hs
		1055441 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DHX8_HUMAN (25-482): 1.24e-127: 428: 22.61
+	Hs
		369828 ESR1_HUMAN (1-595): 0: 599: 100.00		DHX57_HUMAN (155-408): 6.08e-60: 229: 49.23
+	Hs
		1268320 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PRP16_HUMAN (25-482): 4.04e-118: 402: 22.57
+	Hs
		369891 ESR1_HUMAN (1-595): 0: 599: 100.00		DHX30_HUMAN (163-405): 4.25e-41: 167: 39.39
+	Hs
		1269595 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DHX36_HUMAN (71-521): 4.15e-100: 346: 27.63
+	Hs
		1220245 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DHX40_HUMAN (191-481): 5.27e-100: 340: 25.40
+	Hs
		1269619 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DHX33_HUMAN (140-476): 6.02e-99: 335: 25.57
+	Hs
		195343 NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54		DHX15_HUMAN (164-482): 6.33e-112: 374: 26.65
+	Hs
		377471 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		DHX40_HUMAN (191-481): 5.27e-100: 340: 25.40
+	Hs
		1158091 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		DHX57_HUMAN (155-408): 6.08e-60: 229: 49.23
+	Mm
		1142653 ERR2_MOUSE (92-547): 6.98e-113: 345: 34.42		DHX57_MOUSE (176-444): 6.19e-61: 232: 48.36