HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: RAB18 (Q9NP72)
Ras-related protein Rab-18
Gene: RAB18

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31527615, unassigned1953
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 206
+	Hs
		370406 ESR1_HUMAN (1-595): 0: 599: 100.00		RAB1B_HUMAN (1-200): 8.72e-82: 243: 42.57
+	Hs
		369288 ESR1_HUMAN (1-595): 0: 599: 100.00		RAB10_HUMAN (1-199): 1.27e-77: 232: 40.80
+	Hs
		1269688 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		RAB18_HUMAN (1-206): 1.38e-84: 250: 100.00
+	Hs
		918924 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		RAB1A_HUMAN (1-200): 1.22e-82: 245: 43.84
+	Hs
		1269575 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		RAB1B_HUMAN (1-200): 8.72e-82: 243: 42.57
+	Hs
		895531 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		RAB10_HUMAN (1-199): 1.27e-77: 232: 40.80
+	Hs
		377668 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		RAB1B_HUMAN (1-200): 8.72e-82: 243: 42.57
+	Hs
		377213 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		RAB8A_HUMAN (1-206): 1.3e-78: 235: 38.94
+	Hs
		377215 GCR_HUMAN (5-557): 4.67e-109: 346: 22.51		RAB10_HUMAN (1-199): 1.27e-77: 232: 40.80
+	Hs
		487282 ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16		RAB10_HUMAN (1-199): 1.27e-77: 232: 40.80