HitPredict

Interactor 1: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Interactor 2: PNRC2 (Q9NPJ4)
Proline-rich nuclear receptor coactivator 2
Gene: PNRC2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	15604093, 11574675
Identification Methods	two hybrid, beta lactamase complementation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005794 - Golgi apparatus GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 595 Hs			1 139
+	Hs
		1269696 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PNRC2_HUMAN (1-139): 7.18e-68: 203: 100.00
+	Hs
		587199 RXRA_HUMAN (65-551): 4.55e-127: 383: 26.47		PNRC2_HUMAN (1-139): 7.18e-68: 203: 100.00
+	Hs
		1016558 ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88		PNRC1_HUMAN (21-138): 3.26e-54: 174: 41.32
+	Hs
		782667 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		PNRC2_HUMAN (1-139): 7.18e-68: 203: 100.00
+	Hs
		914676 ERR3_HUMAN (91-547): 2.27e-116: 355: 33.77		PNRC2_HUMAN (1-139): 7.18e-68: 203: 100.00
+	Hs
		1055260 HNF4G_HUMAN (174-594): 3.43e-112: 343: 23.28		PNRC2_HUMAN (1-139): 7.18e-68: 203: 100.00
+	Hs
		782531 HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58		PNRC1_HUMAN (21-138): 3.26e-54: 174: 41.32
+	Hs
		914644 ERR3_HUMAN (91-547): 2.27e-116: 355: 33.77		PNRC1_HUMAN (21-138): 3.26e-54: 174: 41.32
+	Hs
		530813 RARG_HUMAN (111-574): 2.15e-103: 321: 23.52		PNRC2_HUMAN (1-139): 7.18e-68: 203: 100.00
+	Hs
		488025 RARA_HUMAN (81-545): 1.35e-102: 320: 22.37		PNRC2_HUMAN (1-139): 7.18e-68: 203: 100.00
+	Hs
		500363 RARB_HUMAN (111-579): 7.62e-114: 349: 22.47		PNRC1_HUMAN (21-138): 3.26e-54: 174: 41.32
+	Hs
		510040 ERR1_HUMAN (123-547): 6.94e-103: 319: 34.04		PNRC2_HUMAN (1-139): 7.18e-68: 203: 100.00
+	Hs
		1016553 HNF4G_HUMAN (174-594): 3.43e-112: 343: 23.28		PNRC1_HUMAN (21-138): 3.26e-54: 174: 41.32
+	Hs
		530793 RARG_HUMAN (111-574): 2.15e-103: 321: 23.52		PNRC1_HUMAN (21-138): 3.26e-54: 174: 41.32
+	Hs
		487957 RARA_HUMAN (81-545): 1.35e-102: 320: 22.37		PNRC1_HUMAN (21-138): 3.26e-54: 174: 41.32