HitPredict

Interactor 1: CFAD (P03953)
Complement factor D (EC 3.4.21.46) (28 kDa adipocyte protein) (Adipsin) (C3 convertase activator) (Properdin factor D)
Gene: Cfd

Interactor 2: LRP1 (Q91ZX7)
Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]
Gene: LRP1

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	30550785
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	EGF~Trypsin, FXa_inhibition~Trypsin, Ldl_recept_a~Trypsin
Common GO terms	-
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 259 Mm			1 4545
+	Mm
		192824 CFAD_MOUSE (1-259): 1.11e-108: 315: 100.00		NOTC2_MOUSE (2796-3070): 1.18e-11: 74.1: 10.88
+	Hs
		980428 TM11B_HUMAN (13-253): 7.08e-99: 296: 31.73		NOTC2_HUMAN (72-288): 1.33e-16: 90.3: 12.27
+	Mm
		371501 CFAD_MOUSE (1-259): 1.11e-108: 315: 100.00		NID1_MOUSE (3451-3674): 4.26e-09: 65.2: 12.81
+	Hs
		371465 KLKB1_HUMAN (3-256): 5.99e-100: 306: 30.30		NID2_HUMAN (4341-4533): 3.69e-10: 69.1: 13.66
+	Hs
		409510 HEPS_HUMAN (15-259): 1.34e-98: 295: 30.68		VLDLR_HUMAN (4245-4499): 1.29e-10: 70.2: 13.43
+	Hs
		258345 KLK15_HUMAN (16-256): 3.77e-97: 286: 36.61		LRP5_HUMAN (1106-1275): 2.83e-10: 69.5: 16.28
+	Hs
		270263 KLK2_HUMAN (1-256): 3.23e-97: 287: 32.59		LRP6_HUMAN (70-283): 3.95e-09: 65.6: 11.44
+	Hs
		270327 KLK15_HUMAN (16-256): 3.77e-97: 286: 36.61		LRP6_HUMAN (70-283): 3.95e-09: 65.6: 11.44
+	Hs
		351104 KLK15_HUMAN (16-256): 3.77e-97: 286: 36.61		LDLR_HUMAN (2450-2658): 4.92e-09: 64.9: 21.01
+	Mm
		378815 GRAB_MOUSE (24-250): 1.05e-42: 147: 33.62		NOTC1_MOUSE (1-219): 9.65e-12: 74.1: 13.10
+	Hs
		270267 CMA1_HUMAN (18-256): 4.69e-39: 137: 33.74		LRP6_HUMAN (70-283): 3.95e-09: 65.6: 11.44
+	Hs
		621380 CMA1_HUMAN (18-256): 4.69e-39: 137: 33.74		SORL_HUMAN (2839-3077): 4.39e-09: 65.6: 16.12
+	Hs
		258288 KLK3_HUMAN (25-256): 3.03e-37: 133: 35.37		LRP5_HUMAN (1106-1275): 2.83e-10: 69.5: 16.28
+	Hs
		351049 CMA1_HUMAN (18-256): 4.69e-39: 137: 33.74		LDLR_HUMAN (2450-2658): 4.92e-09: 64.9: 21.01
+	Hs
		270253 KLK3_HUMAN (25-256): 3.03e-37: 133: 35.37		LRP6_HUMAN (70-283): 3.95e-09: 65.6: 11.44