HitPredict

Interactor 1: MYCN (P03966)
N-myc proto-oncogene protein
Gene: MYCN

Interactor 2: MAX (P28574)
Protein max (Myc-associated factor X) (Myc-binding novel HLH/LZ protein) (Protein myn)
Gene: MAX

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.726

Property	Details
Experiments	20211142, 20946988
Identification Methods	two hybrid array, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II and 1 others more... GO:0046983 - protein dimerization activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 462 Mm			1 160
+	Mm
		348399 MYCN_MOUSE (1-462): 2.21e-92: 289: 100.00		MYC_MOUSE (11-105): 1.39e-23: 97.2: 34.69
+	Hs
		379188 MYCN_HUMAN (1-462): 1.6e-86: 274: 83.87		MAX_HUMAN (1-160): 1.08e-30: 110: 99.38
+	Hs
		345658 MYCN_HUMAN (1-462): 1.6e-86: 274: 83.87		MYC_HUMAN (11-107): 8.31e-25: 100: 33.00
+	Hs
		378891 MYCN_HUMAN (1-462): 1.6e-86: 274: 83.87		MYCN_HUMAN (9-100): 6.86e-21: 89.9: 32.26
+	Rn
		449464 MYC_RAT (5-461): 1.91e-75: 245: 35.20		MAX_RAT (1-160): 2.95e-32: 114: 99.38
+	Mm
		348406 MYC_MOUSE (5-461): 1.31e-75: 245: 35.40		MAX_MOUSE (1-160): 1.21e-31: 112: 100.00
+	Hs
		347688 MYC_HUMAN (7-461): 1.31e-73: 240: 35.00		MNT_HUMAN (7-152): 1.58e-29: 114: 23.90
+	Hs
		346390 MYC_HUMAN (7-461): 1.31e-73: 240: 35.00		MAX_HUMAN (1-160): 1.08e-30: 110: 99.38
+	Hs
		345631 MYC_HUMAN (7-461): 1.31e-73: 240: 35.00		MYC_HUMAN (11-107): 8.31e-25: 100: 33.00
+	Hs
		346785 MYC_HUMAN (7-461): 1.31e-73: 240: 35.00		MAD4_HUMAN (4-159): 9.2e-26: 99.2: 13.38
+	Gg
		348453 MYC_CHICK (14-461): 1.17e-68: 227: 34.21		MAX_CHICK (1-160): 1.41e-30: 109: 95.00
+	Mm
		139602 MLXIP_MOUSE (10-456): 7.46e-43: 163: 14.08		MLX_MOUSE (3-148): 8.76e-27: 103: 23.08
+	Hs
		519709 MYCL_HUMAN (19-461): 4.42e-42: 154: 26.99		MAX_HUMAN (1-160): 1.08e-30: 110: 99.38
+	Hs
		1334775 MLXIP_HUMAN (10-456): 1.12e-41: 160: 12.99		MLX_HUMAN (3-148): 8.23e-27: 103: 23.08
+	Mm
		486429 MYCL_MOUSE (19-461): 1.26e-39: 148: 25.44		MAX_MOUSE (1-160): 1.21e-31: 112: 100.00
+	At
		1323537 MYC3_ARATH (233-462): 8.85e-41: 155: 20.85		MYC3_ARATH (8-126): 1.77e-25: 103: 18.49
+	At
		1107239 MYC3_ARATH (233-462): 8.85e-41: 155: 20.85		MYC2_ARATH (2-117): 5.78e-25: 101: 20.64
+	At
		222019 MYC3_ARATH (233-462): 8.85e-41: 155: 20.85		MYC4_ARATH (8-98): 1.7e-24: 100: 24.18