Interactor 1: VTNC (P04004)
Vitronectin (VN) (S-protein) (Serum-spreading factor) (V75) [Cleaved into: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin-B]
Gene: VTN

Interactor 2: PAI1 (P05121)
Plasminogen activator inhibitor 1 (PAI) (PAI-1) (Endothelial plasminogen activator inhibitor) (Serpin E1)
Gene: SERPINE1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.60 1.00 0.778

The method score is based on:

Property Details
Experiments 11113116, 12808446
Identification Methods pull down, x-ray crystallography
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Serpin~Somatomedin_B
Common GO terms GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0010951 - negative regulation of endopeptidase activity
GO:0030195 - negative regulation of blood coagulation
GO:0048260 - positive regulation of receptor-mediated endocytosis
and 4 others

more...

Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 478
Hs

1 402
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024