HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: PDIA1 (P07237)
Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55)
Gene: P4HB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	36244648, 38496616
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0019899 - enzyme binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 508
+	Hs
		373750 RAF1_HUMAN (1-648): 0: 652: 100.00		PDIA3_HUMAN (2-495): 1.97e-121: 367: 31.57
+	Hs
		423128 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		PDIA1_HUMAN (1-508): 6.42e-154: 450: 100.00
+	Hs
		423113 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		PDIA1_HUMAN (1-508): 6.42e-154: 450: 100.00
+	Hs
		373617 RAF1_HUMAN (1-648): 0: 652: 100.00		PDIA4_HUMAN (330-505): 3.94e-23: 104: 22.22
+	Hs
		374510 RAF1_HUMAN (1-648): 0: 652: 100.00		DJC10_HUMAN (248-481): 6.3e-22: 101: 18.38
+	Hs
		374258 RAF1_HUMAN (1-648): 0: 652: 100.00		PDIA6_HUMAN (372-462): 5.71e-09: 60.1: 36.26
+	Hs
		522950 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		PDIA2_HUMAN (380-507): 1.39e-25: 111: 26.52
+	Hs
		412164 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		PDIA2_HUMAN (380-507): 1.39e-25: 111: 26.52
+	Hs
		412201 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		PDIA6_HUMAN (372-462): 5.71e-09: 60.1: 36.26