HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: ANXA5 (P08758)
Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CPB-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha)
Gene: ANXA5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	36244648, 38496616
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0043066 - negative regulation of apoptotic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 320
+	Hs
		373898 RAF1_HUMAN (1-648): 0: 652: 100.00		ANX11_HUMAN (6-320): 1.35e-179: 507: 53.65
+	Hs
		373567 RAF1_HUMAN (1-648): 0: 652: 100.00		ANXA4_HUMAN (7-320): 5.12e-173: 483: 58.60
+	Hs
		373535 RAF1_HUMAN (1-648): 0: 652: 100.00		ANXA2_HUMAN (7-320): 1.73e-154: 437: 46.03
+	Mm
		427714 BRAF_MOUSE (38-647): 3.22e-169: 503: 55.52		ANXA2_MOUSE (7-320): 2.78e-155: 439: 45.40
+	Hs
		376139 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		ANXA1_HUMAN (9-319): 2.11e-151: 429: 44.05
+	Hs
		373546 RAF1_HUMAN (1-648): 0: 652: 100.00		ANXA6_HUMAN (19-318): 2.26e-65: 219: 25.83
+	Mm
		655933 BRAF_MOUSE (38-647): 3.22e-169: 503: 55.52		ANXA5_MOUSE (20-162): 2.69e-22: 96.8: 30.61
+	Hs
		522763 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		ANXA7_HUMAN (172-319): 1.17e-39: 146: 29.05