HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: ENPL (P14625)
Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog)
Gene: HSP90B1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	38496616
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 648 Hs			1 803
+	Hs
		373549 RAF1_HUMAN (1-648): 0: 652: 100.00		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		373543 RAF1_HUMAN (1-648): 0: 652: 100.00		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Hs
		538082 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		ENPL_HUMAN (1-803): 0: 1073: 100.00
+	Hs
		488555 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		ENPL_HUMAN (1-803): 0: 1073: 100.00
+	Mm
		435915 BRAF_MOUSE (38-647): 3.22e-169: 503: 55.52		ENPL_MOUSE (1-803): 0: 1062: 96.64
+	Gg
		435893 BRAF_CHICK (38-647): 1.98e-169: 504: 56.96		ENPL_CHICK (21-803): 0: 1006: 90.29
+	Hs
		437860 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		431496 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Hs
		437832 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Gg
		513713 BRAF_CHICK (38-647): 1.98e-169: 504: 56.96		HS90A_CHICK (60-783): 0: 986: 46.13
+	Mm
		432406 BRAF_MOUSE (38-647): 3.22e-169: 503: 55.52		HS90A_MOUSE (60-783): 0: 985: 45.28
+	Hs
		431459 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Hs
		432156 Q96II5_HUMAN (45-646): 9.01e-168: 494: 58.82		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Dm
		365432 KRAF1_DROME (45-647): 6.35e-165: 491: 44.98		HSP83_DROME (69-783): 0: 981: 45.74
+	Rn
		88624 D3ZHL1_RAT (138-648): 2.7e-114: 365: 26.08		HS90A_RAT (60-783): 0: 988: 45.28
+	Hs
		438332 KSR1_HUMAN (138-648): 6.15e-108: 348: 24.61		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		432033 KSR1_HUMAN (138-648): 6.15e-108: 348: 24.61		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Hs
		437847 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		HS90B_HUMAN (75-783): 0: 997: 46.54
+	Hs
		431481 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		HS90A_HUMAN (60-783): 0: 990: 45.34
+	Zm
		8229 A0A1D6ELX5_MAIZE (134-614): 1.35e-113: 360: 26.82		A0A1D6LMW9_MAIZE (14-781): 0: 889: 46.68