HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: RAB5B (P61020)
Ras-related protein Rab-5B (EC 3.6.5.2)
Gene: RAB5B

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36244648
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, Pkinase~Ras, RBD~Ras
Common GO terms	GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 215
+	Hs
		374007 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB1A_HUMAN (10-213): 8.59e-91: 266: 39.51
+	Hs
		373666 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB5A_HUMAN (1-215): 9.46e-89: 262: 81.86
+	Hs
		374854 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB1B_HUMAN (13-213): 4.44e-89: 262: 39.30
+	Hs
		373901 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB5C_HUMAN (1-215): 7.24e-88: 259: 84.26
+	Hs
		374003 RAF1_HUMAN (1-648): 0: 652: 100.00		RB11A_HUMAN (10-215): 2.59e-86: 255: 38.61
+	Hs
		373973 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB8A_HUMAN (14-211): 1.25e-85: 253: 34.85
+	Hs
		374852 RAF1_HUMAN (1-648): 0: 652: 100.00		RAB17_HUMAN (3-215): 5.09e-50: 163: 40.65
+	Hs
		542851 BRAF_HUMAN (39-647): 1.29e-170: 507: 55.88		RAB1A_HUMAN (10-213): 8.59e-91: 266: 39.51
+	Hs
		488650 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		RB11A_HUMAN (10-215): 2.59e-86: 255: 38.61
+	Hs
		433251 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		RAB5A_HUMAN (1-215): 9.46e-89: 262: 81.86
+	Hs
		433295 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		RAB5C_HUMAN (1-215): 7.24e-88: 259: 84.26
+	Hs
		522882 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		RB11A_HUMAN (10-215): 2.59e-86: 255: 38.61
+	Hs
		433312 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		RB11A_HUMAN (10-215): 2.59e-86: 255: 38.61
+	Hs
		523004 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		RB11B_HUMAN (10-215): 3.73e-85: 252: 39.63