HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36244648
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~Ras, Pkinase~Ras, RBD~Ras
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0019899 - enzyme binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 192
+	Hs
		373547 RAF1_HUMAN (1-648): 0: 652: 100.00		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Hs
		522888 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		433314 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		433244 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Hs
		412123 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		433239 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		433475 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Hs
		411980 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		433304 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		433322 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		433305 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		433307 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		412113 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		412115 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		433217 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Hs
		411948 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Hs
		894147 KSR2_HUMAN (332-623): 6.72e-43: 168: 34.43		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31