HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: SHC3 (Q92529)
SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3)
Gene: SHC3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36244648
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~SH2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 594
+	Hs
		522805 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		SHC1_HUMAN (3-593): 5.76e-176: 512: 46.65
+	Hs
		433266 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		SHC1_HUMAN (3-593): 5.76e-176: 512: 46.65
+	Hs
		373611 RAF1_HUMAN (1-648): 0: 652: 100.00		SRC_HUMAN (361-594): 3.73e-49: 181: 18.18
+	Hs
		373521 RAF1_HUMAN (1-648): 0: 652: 100.00		FYN_HUMAN (438-585): 3.12e-44: 167: 20.76
+	Dm
		507710 KRAF1_DROME (45-647): 6.35e-165: 491: 44.98		GRAP_DROME (493-593): 3.92e-12: 67.5: 27.89
+	Hs
		522734 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		SRC_HUMAN (361-594): 3.73e-49: 181: 18.18
+	Hs
		433231 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		YES_HUMAN (355-594): 1.37e-48: 179: 17.31
+	Gg
		337663 SRC_CHICK (331-607): 2.94e-106: 333: 33.45		SRC_CHICK (360-594): 2.88e-48: 178: 17.00
+	Hs
		433215 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		YES_HUMAN (355-594): 1.37e-48: 179: 17.31
+	Hs
		442772 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		HCK_HUMAN (360-594): 1.32e-47: 176: 15.54
+	Hs
		454794 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		FGR_HUMAN (359-594): 1.87e-47: 175: 18.22
+	Hs
		433222 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		FGR_HUMAN (359-594): 1.87e-47: 175: 18.22
+	Hs
		522840 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		ABL2_HUMAN (342-592): 8.81e-45: 173: 15.91
+	Hs
		411969 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		FYN_HUMAN (438-585): 3.12e-44: 167: 20.76
+	Hs
		411946 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		FYN_HUMAN (438-585): 3.12e-44: 167: 20.76
+	Hs
		433546 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		LYN_HUMAN (404-594): 8.1e-44: 165: 20.69
+	Hs
		433216 YES_HUMAN (329-607): 1.22e-105: 332: 33.92		LYN_HUMAN (404-594): 8.1e-44: 165: 20.69
+	Hs
		523000 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		SHB_HUMAN (363-590): 9.97e-43: 162: 22.36
+	Hs
		522887 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		GRB2_HUMAN (445-594): 1.28e-34: 132: 22.08