HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: MED12 (Q93074)
Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)
Gene: MED12

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	38496616
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0014044 - Schwann cell development GO:0035019 - somatic stem cell population maintenance GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 2177
+	Hs
		374841 RAF1_HUMAN (1-648): 0: 652: 100.00		WDR33_HUMAN (1594-2167): 1.1e-24: 115: 8.81
+	Hs
		374792 RAF1_HUMAN (1-648): 0: 652: 100.00		DIDO1_HUMAN (1479-2099): 1.5e-18: 95.4: 10.74
+	Hs
		358583 RAF1_HUMAN (1-648): 0: 652: 100.00		CO2A1_HUMAN (1603-2086): 2.19e-14: 81.5: 11.42
+	Hs
		373519 RAF1_HUMAN (1-648): 0: 652: 100.00		CO5A2_HUMAN (1590-2058): 1.16e-11: 72.7: 11.32
+	Hs
		302235 RAF1_HUMAN (1-648): 0: 652: 100.00		SC31A_HUMAN (1897-2176): 1.29e-11: 72.3: 11.54
+	Hs
		374751 RAF1_HUMAN (1-648): 0: 652: 100.00		ATX2_HUMAN (1645-2176): 2.64e-11: 71.5: 9.32
+	Hs
		375013 RAF1_HUMAN (1-648): 0: 652: 100.00		CHD7_HUMAN (1825-2174): 2.18e-10: 68.8: 10.05
+	Hs
		374709 RAF1_HUMAN (1-648): 0: 652: 100.00		EP400_HUMAN (1812-2174): 7.89e-09: 63.4: 17.63
+	Hs
		488793 ARAF_HUMAN (45-646): 4.63e-169: 497: 59.28		DIDO1_HUMAN (1479-2099): 1.5e-18: 95.4: 10.74
+	Ce
		136795 KRAF1_CAEEL (50-627): 1.76e-151: 459: 35.95		UNC89_CAEEL (1599-2149): 1.94e-20: 101: 10.83
+	Hs
		523092 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		CBP_HUMAN (1582-2176): 2.69e-11: 71.5: 13.45
+	Hs
		523123 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		ATX2_HUMAN (1645-2176): 2.64e-11: 71.5: 9.32
+	Hs
		64077 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		L37A2_HUMAN (1785-2176): 1.71e-10: 68.8: 10.86
+	Hs
		522986 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		NCOA6_HUMAN (1716-2173): 1.71e-09: 65.7: 11.91
+	Mm
		70886 SRC_MOUSE (331-607): 3.87e-105: 330: 33.10		EP300_MOUSE (1845-2169): 2.28e-10: 68.7: 22.10
+	Mm
		250683 SRC_MOUSE (331-607): 3.87e-105: 330: 33.10		ATX2_MOUSE (1644-2170): 6.85e-09: 63.4: 11.90