HitPredict

Interactor 1: RAF1 (P04049)
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)
Gene: RAF1

Interactor 2: UHRF1 (Q96T88)
E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)
Gene: UHRF1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36244648
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 648 Hs			1 793
+	Hs
		412314 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		UHRF2_HUMAN (1-793): 0: 774: 53.01
+	Hs
		374134 RAF1_HUMAN (1-648): 0: 652: 100.00		CHD3_HUMAN (101-502): 7.48e-52: 198: 13.90
+	Hs
		374244 RAF1_HUMAN (1-648): 0: 652: 100.00		CHD4_HUMAN (233-502): 9.71e-49: 189: 15.00
+	Hs
		373737 RAF1_HUMAN (1-648): 0: 652: 100.00		KDM5A_HUMAN (274-383): 9.75e-20: 97.2: 27.27
+	Hs
		374227 RAF1_HUMAN (1-648): 0: 652: 100.00		TRI25_HUMAN (715-786): 9.14e-20: 96.1: 31.08
+	Zm
		28103 A0A1D6JP61_MAIZE (273-627): 7.9e-105: 342: 29.14		A0A1D6N2J4_MAIZE (230-637): 5.97e-67: 236: 19.95
+	Hs
		522990 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		CHD4_HUMAN (233-502): 9.71e-49: 189: 15.00
+	Hs
		412395 FYN_HUMAN (337-607): 2.33e-103: 326: 34.55		BAZ2A_HUMAN (138-417): 1.39e-38: 157: 17.87
+	Hs
		522983 SRC_HUMAN (331-607): 3.01e-106: 333: 33.45		TRI25_HUMAN (715-786): 9.14e-20: 96.1: 31.08