HitPredict

Interactor 1: CSF2 (P04141)
Granulocyte-macrophage colony-stimulating factor (GM-CSF) (Colony-stimulating factor) (CSF) (Molgramostin) (Sargramostim)
Gene: CSF2

Interactor 2: CSF2R (P15509)
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (GM-CSF-R-alpha) (GMCSFR-alpha) (GMR-alpha) (CDw116) (CD antigen CD116)
Gene: CSF2RA

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.73 1.00 0.858

The method score is based on:

Property Details
Experiments 7957082, 27396825, 2555171
Identification Methods pull down, biochemical, molecular sieving, x-ray crystallography, experimental interaction detection
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains GM_CSF~IL3Ra_N, GM_CSF~IL6Ra-bind
Common GO terms GO:0005576 - extracellular region
GO:0005886 - plasma membrane
GO:0007259 - cell surface receptor signaling pathway via JAK-STAT
GO:0030526 - granulocyte macrophage colony-stimulating factor receptor complex
GO:0038157 - granulocyte-macrophage colony-stimulating factor signaling pathway
and 1 others

more...
Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 144
Hs

1 400
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024