HitPredict

Interactor 1: GCR (P04150)
Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1)
Gene: NR3C1

Interactor 2: FKBP4 (Q02790)
Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (51 kDa FK506-binding protein) (FKBP51) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed]
Gene: FKBP4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.705

Property	Details
Experiments	16131566, 8341706, 25132599, 15004035, 20661446
Identification Methods	affinity chromatography technology, pull down, protein complementation assay
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 777 Hs			1 459
+	Hs
		377301 GCR_HUMAN (1-777): 0: 933: 100.00		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Mm
		415156 GCR_MOUSE (1-777): 0: 861: 88.18		FKBP4_MOUSE (1-459): 2.03e-148: 432: 89.76
+	Mm
		415159 GCR_MOUSE (1-777): 0: 861: 88.18		FKBP5_MOUSE (1-451): 1.47e-136: 402: 53.66
+	Hs
		377276 GCR_HUMAN (1-777): 0: 933: 100.00		PPID_HUMAN (251-416): 8.47e-51: 177: 28.14
+	Hs
		377132 GCR_HUMAN (1-777): 0: 933: 100.00		STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51
+	Hs
		369442 ESR1_HUMAN (263-760): 1.11e-129: 400: 23.06		FKBP4_HUMAN (1-459): 1.71e-150: 437: 100.00
+	Hs
		437634 MCR_HUMAN (130-777): 7.96e-114: 370: 39.54		FKBP4_HUMAN (1-459): 1.71e-150: 437: 100.00
+	Hs
		369544 ESR1_HUMAN (263-760): 1.11e-129: 400: 23.06		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Hs
		414489 PRGR_HUMAN (232-777): 2.39e-110: 359: 40.00		FKBP4_HUMAN (1-459): 1.71e-150: 437: 100.00
+	Hs
		437640 MCR_HUMAN (130-777): 7.96e-114: 370: 39.54		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Hs
		414500 PRGR_HUMAN (232-777): 2.39e-110: 359: 40.00		FKBP5_HUMAN (1-456): 2.91e-138: 406: 54.83
+	Hs
		369479 ESR1_HUMAN (263-760): 1.11e-129: 400: 23.06		PPID_HUMAN (251-416): 8.47e-51: 177: 28.14
+	Hs
		370658 ESR1_HUMAN (263-760): 1.11e-129: 400: 23.06		FKBPL_HUMAN (135-415): 6.34e-49: 172: 26.15
+	Hs
		437638 MCR_HUMAN (130-777): 7.96e-114: 370: 39.54		PPID_HUMAN (251-416): 8.47e-51: 177: 28.14
+	Hs
		118677 MCR_HUMAN (130-777): 7.96e-114: 370: 39.54		AIP_HUMAN (146-416): 1.8e-50: 176: 20.12
+	Hs
		369598 ESR1_HUMAN (263-760): 1.11e-129: 400: 23.06		FKBP8_HUMAN (26-337): 2.99e-32: 128: 18.30
+	Hs
		369072 ESR1_HUMAN (263-760): 1.11e-129: 400: 23.06		STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51
+	Hs
		1053109 ESR2_HUMAN (286-769): 2.89e-107: 339: 21.34		FKBP8_HUMAN (26-337): 2.99e-32: 128: 18.30
+	Hs
		414449 PRGR_HUMAN (232-777): 2.39e-110: 359: 40.00		STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51
+	Hs
		487173 ANDR_HUMAN (357-777): 2.54e-100: 332: 45.15		STIP1_HUMAN (259-458): 6.41e-12: 69.5: 11.51