HitPredict

Interactor 1: GCR (P04150)
Glucocorticoid receptor (GR) (Nuclear receptor subfamily 3 group C member 1)
Gene: NR3C1

Interactor 2: NCOA6 (Q14686)
Nuclear receptor coactivator 6 (Activating signal cointegrator 2) (ASC-2) (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Nuclear receptor-activating protein, 250 kDa) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Thyroid hormone receptor-binding protein)
Gene: NCOA6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.707

Property	Details
Experiments	28611094, 31182584, 36613751, 10567404, 10866662
Identification Methods	proximity labelling technology, unspecified method, pull down, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 777 Hs			1 2063
+	Hs
		369612 ESR1_HUMAN (263-760): 1.11e-129: 400: 23.06		NCOA6_HUMAN (1-2063): 0: 746: 100.00
+	Hs
		587169 RXRA_HUMAN (292-759): 1.24e-123: 380: 21.14		NCOA6_HUMAN (1-2063): 0: 746: 100.00
+	Hs
		131683 GCR_HUMAN (1-777): 0: 933: 100.00		BCL9_HUMAN (109-1440): 4.55e-36: 152: 9.92
+	Hs
		377537 GCR_HUMAN (1-777): 0: 933: 100.00		MUC16_HUMAN (157-2025): 1.37e-22: 109: 8.29
+	Hs
		377839 GCR_HUMAN (1-777): 0: 933: 100.00		NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11
+	Hs
		377808 GCR_HUMAN (1-777): 0: 933: 100.00		BSN_HUMAN (160-1946): 1.34e-14: 82.5: 8.40
+	Hs
		377505 GCR_HUMAN (1-777): 0: 933: 100.00		ARI1B_HUMAN (582-2022): 5.83e-14: 80.2: 10.54
+	Hs
		377760 GCR_HUMAN (1-777): 0: 933: 100.00		CHD7_HUMAN (169-662): 2.63e-11: 71.8: 12.93
+	Hs
		377624 GCR_HUMAN (1-777): 0: 933: 100.00		MINT_HUMAN (1100-2062): 1.16e-09: 66.2: 9.24
+	Hs
		370417 ESR1_HUMAN (263-760): 1.11e-129: 400: 23.06		TARA_HUMAN (168-1726): 1.14e-25: 118: 9.69
+	Hs
		368927 ESR1_HUMAN (263-760): 1.11e-129: 400: 23.06		MUC1_HUMAN (159-883): 4.81e-23: 110: 10.47
+	Hs
		370824 ESR1_HUMAN (263-760): 1.11e-129: 400: 23.06		NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11
+	Hs
		369171 ESR1_HUMAN (263-760): 1.11e-129: 400: 23.06		PRC2A_HUMAN (208-2062): 5.88e-16: 86.8: 7.66
+	Hs
		587211 RXRA_HUMAN (292-759): 1.24e-123: 380: 21.14		NCOR2_HUMAN (296-2055): 1.78e-19: 98.3: 8.11
+	Hs
		369607 ESR1_HUMAN (263-760): 1.11e-129: 400: 23.06		MDC1_HUMAN (157-945): 1.46e-12: 75.8: 11.15
+	Hs
		370607 ESR1_HUMAN (263-760): 1.11e-129: 400: 23.06		CHD7_HUMAN (169-662): 2.63e-11: 71.8: 12.93
+	Hs
		370040 ESR1_HUMAN (263-760): 1.11e-129: 400: 23.06		KMT2C_HUMAN (535-1739): 1.33e-10: 69.2: 11.23
+	Hs
		370263 ESR1_HUMAN (263-760): 1.11e-129: 400: 23.06		MINT_HUMAN (1100-2062): 1.16e-09: 66.2: 9.24
+	Mm
		99856 ESR1_MOUSE (263-760): 2.73e-126: 391: 22.51		F6M2J9_MOUSE (339-1212): 9.08e-12: 72.9: 10.93
+	Hs
		370728 ESR1_HUMAN (263-760): 1.11e-129: 400: 23.06		SRRM2_HUMAN (1328-2061): 5.87e-09: 63.7: 10.47