Interactor 1: IL1A (P01583)
Interleukin-1 alpha (IL-1 alpha) (Hematopoietin-1)
Gene: IL1A
Interactor 2: CASP1 (P29466)
Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
Gene: CASP1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.44 | 0.90 | 0.631 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 18329368 |
| Identification Methods | anti bait coimmunoprecipitation, anti tag coimmunoprecipitation |
| Interaction Type | physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | IL1~Peptidase_C14 |
| Common GO terms | GO:0005829 - cytosol GO:0006915 - apoptotic process GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0071222 - cellular response to lipopolysaccharide |
| Homologous interactions | 0 |
Service provided by Combinatics, Japan
Last updated: 11Aug2025
