Interactor 1: EPO (P01588)
Erythropoietin (Epoetin)
Gene: EPO
Interactor 2: EPOR (P19235)
Erythropoietin receptor (EPO-R)
Gene: EPOR
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.95 | 0.90 | 0.927 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 15358619, 28514442, 29997244, 10318834, 9808045, 17327410, 8662939, 9774108, 9030560, 26481148 |
| Identification Methods | two hybrid, affinity chromatography technology, pull down, biochemical, x-ray crystallography, surface plasmon resonance, microscale thermophoresis, luminescence based mammalian interactome mapping, anti tag coimmunoprecipitation |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | EPO_TPO~EpoR_lig-bind, EPO_TPO~fn3 |
| Common GO terms | GO:0005576 - extracellular region GO:0007165 - signal transduction GO:0008284 - positive regulation of cell population proliferation GO:0038162 - erythropoietin-mediated signaling pathway |
| Homologous interactions | 0 |
Service provided by Combinatics, Japan
Last updated: 11Aug2025
