HitPredict

Interactor 1: K2C1 (P04264)
Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1)
Gene: KRT1

Interactor 2: EFNA1 (P20827)
Ephrin-A1 (EPH-related receptor tyrosine kinase ligand 1) (LERK-1) (Immediate early response protein B61) (Tumor necrosis factor alpha-induced protein 4) (TNF alpha-induced protein 4) [Cleaved into: Ephrin-A1, secreted form]
Gene: EFNA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23686814
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0045765 - regulation of angiogenesis
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 644 Hs			1 205
+	Hs
		531533 K2C5_HUMAN (1-496): 2.32e-82: 272: 64.32		EFNA1_HUMAN (1-205): 2.54e-101: 293: 100.00
+	Hs
		380444 K2C6B_HUMAN (2-512): 5.16e-79: 263: 62.82		EFNA1_HUMAN (1-205): 2.54e-101: 293: 100.00
+	Hs
		595981 K2C6C_HUMAN (2-512): 2.69e-78: 261: 62.62		EFNA1_HUMAN (1-205): 2.54e-101: 293: 100.00
+	Hs
		359465 K2C6A_HUMAN (2-512): 2.12e-75: 253: 62.43		EFNA1_HUMAN (1-205): 2.54e-101: 293: 100.00
+	Hs
		856412 K2C73_HUMAN (1-582): 1.37e-90: 292: 51.63		EFNA4_HUMAN (4-170): 8.07e-61: 190: 39.88
+	Hs
		531543 K2C5_HUMAN (1-496): 2.32e-82: 272: 64.32		EFNA3_HUMAN (14-187): 1.51e-67: 208: 40.00
+	Hs
		856361 KRT83_HUMAN (79-563): 3.51e-87: 282: 44.47		EFNA4_HUMAN (4-170): 8.07e-61: 190: 39.88
+	Hs
		380453 K2C6B_HUMAN (2-512): 5.16e-79: 263: 62.82		EFNA3_HUMAN (14-187): 1.51e-67: 208: 40.00
+	Hs
		821644 K2C6C_HUMAN (2-512): 2.69e-78: 261: 62.62		EFNA3_HUMAN (14-187): 1.51e-67: 208: 40.00
+	Hs
		856320 K2C71_HUMAN (1-574): 1.29e-78: 261: 52.09		EFNA3_HUMAN (14-187): 1.51e-67: 208: 40.00
+	Hs
		380583 K2C1_HUMAN (1-511): 2.63e-77: 260: 100.00		EFNA3_HUMAN (14-187): 1.51e-67: 208: 40.00
+	Hs
		531544 K2C5_HUMAN (1-496): 2.32e-82: 272: 64.32		EFNA4_HUMAN (4-170): 8.07e-61: 190: 39.88
+	Hs
		359473 K2C6A_HUMAN (2-512): 2.12e-75: 253: 62.43		EFNA3_HUMAN (14-187): 1.51e-67: 208: 40.00
+	Hs
		856362 KRT85_HUMAN (69-552): 3.19e-81: 267: 44.88		EFNA4_HUMAN (4-170): 8.07e-61: 190: 39.88
+	Hs
		380454 K2C6B_HUMAN (2-512): 5.16e-79: 263: 62.82		EFNA4_HUMAN (4-170): 8.07e-61: 190: 39.88
+	Hs
		821645 K2C6C_HUMAN (2-512): 2.69e-78: 261: 62.62		EFNA4_HUMAN (4-170): 8.07e-61: 190: 39.88
+	Hs
		380584 K2C1_HUMAN (1-511): 2.63e-77: 260: 100.00		EFNA4_HUMAN (4-170): 8.07e-61: 190: 39.88
+	Hs
		856473 KRT82_HUMAN (61-575): 4.79e-77: 256: 44.85		EFNA4_HUMAN (4-170): 8.07e-61: 190: 39.88
+	Hs
		359474 K2C6A_HUMAN (2-512): 2.12e-75: 253: 62.43		EFNA4_HUMAN (4-170): 8.07e-61: 190: 39.88