HitPredict

Interactor 1: K2C1 (P04264)
Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1)
Gene: KRT1

Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	36470425, 19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 644 Hs			1 906
+	Hs
		610513 KRT84_HUMAN (3-644): 8.54e-97: 311: 44.36		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		531534 K2C5_HUMAN (1-496): 2.32e-82: 272: 64.32		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		380445 K2C6B_HUMAN (2-512): 5.16e-79: 263: 62.82		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		610295 K2C6C_HUMAN (2-512): 2.69e-78: 261: 62.62		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		610433 K2C79_HUMAN (28-570): 6.02e-78: 259: 56.15		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		359466 K2C6A_HUMAN (2-512): 2.12e-75: 253: 62.43		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		517738 K2C3_HUMAN (152-497): 1.64e-62: 220: 74.71		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		203197 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		SYNJ1_HUMAN (542-897): 2.72e-14: 79.6: 10.22
+	Hs
		409194 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		ASPP1_HUMAN (445-844): 1.47e-10: 67.3: 10.25
+	Hs
		580149 K2C4_HUMAN (11-505): 1.78e-66: 228: 58.99		ASPP1_HUMAN (445-844): 1.47e-10: 67.3: 10.25