HitPredict

Interactor 1: K2C1 (P04264)
Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1)
Gene: KRT1

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 644 Hs			1 304
+	Hs
		409026 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		802658 K2C78_HUMAN (119-543): 1.51e-130: 395: 55.09		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		409124 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		DNMBP_HUMAN (119-293): 5.7e-46: 168: 29.35
+	Hs
		409046 K2C8_HUMAN (152-543): 4.05e-144: 429: 59.44		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		444533 K2C7_HUMAN (138-505): 3.95e-137: 410: 60.33		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		802647 K2C73_HUMAN (1-582): 1.37e-90: 292: 51.63		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		531539 K2C5_HUMAN (1-496): 2.32e-82: 272: 64.32		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		380448 K2C6B_HUMAN (2-512): 5.16e-79: 263: 62.82		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		802619 K2C79_HUMAN (28-570): 6.02e-78: 259: 56.15		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		359471 K2C6A_HUMAN (2-512): 2.12e-75: 253: 62.43		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		802568 K22O_HUMAN (1-508): 2.87e-69: 239: 60.00		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		924679 K2C73_HUMAN (1-582): 1.37e-90: 292: 51.63		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		924469 KRT83_HUMAN (79-563): 3.51e-87: 282: 44.47		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		924576 KRT81_HUMAN (79-568): 2.1e-86: 281: 44.42		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		213936 KRT86_HUMAN (79-558): 5.38e-84: 274: 43.69		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		531551 K2C5_HUMAN (1-496): 2.32e-82: 272: 64.32		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		924470 KRT85_HUMAN (69-552): 3.19e-81: 267: 44.88		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		380590 K2C1_HUMAN (1-511): 2.63e-77: 260: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		924895 KRT82_HUMAN (61-575): 4.79e-77: 256: 44.85		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		359480 K2C6A_HUMAN (2-512): 2.12e-75: 253: 62.43		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67