HitPredict

Interactor 1: S100B (P04271)
Protein S100-B (S-100 protein beta chain) (S-100 protein subunit beta) (S100 calcium-binding protein B)
Gene: S100B

Interactor 2: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.874

Property	Details
Experiments	15178678, 17010455, 20591429, 31837246
Identification Methods	affinity chromatography technology, unspecified method, molecular sieving, fluorescence polarization spectroscopy
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	S_100~TAD2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008270 - zinc ion binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 92 Hs			1 393
+	Hs
		387043 HORN_HUMAN (1-92): 1.99e-34: 125: 30.44		P53_HUMAN (1-393): 0: 619: 100.00
+	Hs
		386132 S100P_HUMAN (1-91): 2.35e-34: 114: 50.55		P53_HUMAN (1-393): 0: 619: 100.00
+	Hs
		386185 S10AB_HUMAN (2-91): 3e-33: 112: 35.56		P53_HUMAN (1-393): 0: 619: 100.00
+	Hs
		386865 FILA2_HUMAN (1-92): 4.58e-30: 112: 36.96		P53_HUMAN (1-393): 0: 619: 100.00
+	Hs
		386104 S10A1_HUMAN (2-89): 2.93e-33: 111: 60.23		P53_HUMAN (1-393): 0: 619: 100.00
+	Hs
		386137 S10A4_HUMAN (3-90): 2.3e-30: 104: 47.73		P53_HUMAN (1-393): 0: 619: 100.00
+	Hs
		386155 S10A2_HUMAN (2-90): 1.34e-29: 102: 44.94		P53_HUMAN (1-393): 0: 619: 100.00
+	Hs
		386412 S10AA_HUMAN (2-89): 2.16e-29: 102: 38.64		P53_HUMAN (1-393): 0: 619: 100.00
+	Hs
		386512 S10AC_HUMAN (1-92): 2.11e-29: 102: 38.04		P53_HUMAN (1-393): 0: 619: 100.00
+	Hs
		386192 S10A3_HUMAN (3-90): 1.74e-28: 100: 38.64		P53_HUMAN (1-393): 0: 619: 100.00
+	Hs
		385910 S10A8_HUMAN (1-92): 4.18e-25: 91.4: 32.61		P53_HUMAN (1-393): 0: 619: 100.00
+	Hs
		385924 S10A6_HUMAN (3-90): 7.15e-24: 87.9: 39.77		P53_HUMAN (1-393): 0: 619: 100.00
+	Hs
		387288 S10AG_HUMAN (2-92): 8.88e-23: 85.6: 28.26		P53_HUMAN (1-393): 0: 619: 100.00
+	Hs
		386191 S10A5_HUMAN (2-92): 2.82e-22: 84.1: 39.56		P53_HUMAN (1-393): 0: 619: 100.00
+	Hs
		386596 TRHY_HUMAN (1-91): 1.38e-19: 83.3: 31.87		P53_HUMAN (1-393): 0: 619: 100.00
+	Hs
		387371 S10AD_HUMAN (1-83): 3.55e-21: 81.4: 28.92		P53_HUMAN (1-393): 0: 619: 100.00