HitPredict

Interactor 1: S100B (P04271)
Protein S100-B (S-100 protein beta chain) (S-100 protein subunit beta) (S100 calcium-binding protein B)
Gene: S100B

Interactor 2: TRPM4 (Q8TD43)
Transient receptor potential cation channel subfamily M member 4 (hTRPM4) (Calcium-activated non-selective cation channel 1) (Long transient receptor potential channel 4) (LTrpC-4) (LTrpC4) (Melastatin-4)
Gene: TRPM4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	31837246
Identification Methods	fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0008284 - positive regulation of cell population proliferation GO:0043025 - neuronal cell body
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 92 Hs			1 1214
+	Hs
		639026 S100P_HUMAN (1-91): 2.35e-34: 114: 50.55		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		685179 S10AB_HUMAN (2-91): 3e-33: 112: 35.56		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		615221 S10A1_HUMAN (2-89): 2.93e-33: 111: 60.23		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		642972 S10A4_HUMAN (3-90): 2.3e-30: 104: 47.73		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		416480 S10A9_HUMAN (1-91): 3.59e-29: 102: 36.96		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		661361 S10A2_HUMAN (2-90): 1.34e-29: 102: 44.94		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		893818 S10AA_HUMAN (2-89): 2.16e-29: 102: 38.64		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		707382 S10A3_HUMAN (3-90): 1.74e-28: 100: 38.64		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		396768 S10A8_HUMAN (1-92): 4.18e-25: 91.4: 32.61		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		416665 S10A6_HUMAN (3-90): 7.15e-24: 87.9: 39.77		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		707352 S10A5_HUMAN (2-92): 2.82e-22: 84.1: 39.56		TRPM4_HUMAN (1-1214): 0: 1243: 100.00
+	Hs
		1254558 S10AE_HUMAN (2-83): 1.74e-19: 77.5: 29.27		TRPM4_HUMAN (1-1214): 0: 1243: 100.00