HitPredict

Interactor 1: S100B (P04271)
Protein S100-B (S-100 protein beta chain) (S-100 protein subunit beta) (S100 calcium-binding protein B)
Gene: S100B

Interactor 2: S100Z (Q8WXG8)
Protein S100-Z (S100 calcium-binding protein Z)
Gene: S100Z

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	EF-hand_1~S_100, S_100~S_100
Common GO terms	GO:0005509 - calcium ion binding GO:0042803 - protein homodimerization activity GO:0048306 - calcium-dependent protein binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 92 Hs			1 99
+	Hs
		1135040 Q5T7Y6_HUMAN (2-89): 1.67e-37: 124: 60.23		Q5T7Y6_HUMAN (1-94): 1.52e-41: 134: 57.45
+	Hs
		638981 Q5T7Y6_HUMAN (2-89): 1.67e-37: 124: 60.23		S100P_HUMAN (3-93): 1.58e-34: 115: 51.65
+	Hs
		615201 S100P_HUMAN (1-91): 2.35e-34: 114: 50.55		S10A1_HUMAN (1-94): 6.61e-38: 124: 57.45
+	Hs
		685154 S10AB_HUMAN (2-91): 3e-33: 112: 35.56		S10AB_HUMAN (2-99): 8.78e-39: 126: 31.63
+	Hs
		615200 S10A1_HUMAN (2-89): 2.93e-33: 111: 60.23		S10A1_HUMAN (1-94): 6.61e-38: 124: 57.45
+	Hs
		639031 S100P_HUMAN (1-91): 2.35e-34: 114: 50.55		S100Z_HUMAN (1-99): 5.04e-36: 119: 100.00
+	Hs
		1125327 HORN_HUMAN (1-92): 1.99e-34: 125: 30.44		FILA2_HUMAN (3-93): 5.07e-28: 107: 37.36
+	Hs
		615222 S10A1_HUMAN (2-89): 2.93e-33: 111: 60.23		S100Z_HUMAN (1-99): 5.04e-36: 119: 100.00
+	Hs
		380790 Q5T7Y6_HUMAN (2-89): 1.67e-37: 124: 60.23		S100B_HUMAN (3-93): 1.16e-30: 105: 45.06
+	Hs
		638919 S100P_HUMAN (1-91): 2.35e-34: 114: 50.55		S100P_HUMAN (3-93): 1.58e-34: 115: 51.65
+	Hs
		615203 S10A1_HUMAN (2-89): 2.93e-33: 111: 60.23		S10A4_HUMAN (1-90): 7.21e-33: 111: 46.67
+	Hs
		615204 S10A1_HUMAN (2-89): 2.93e-33: 111: 60.23		S10A2_HUMAN (1-92): 2.41e-32: 109: 42.39
+	Hs
		380738 S100P_HUMAN (1-91): 2.35e-34: 114: 50.55		S100B_HUMAN (3-93): 1.16e-30: 105: 45.06
+	Hs
		380745 S10AB_HUMAN (2-91): 3e-33: 112: 35.56		S100B_HUMAN (3-93): 1.16e-30: 105: 45.06
+	Hs
		615206 S10A1_HUMAN (2-89): 2.93e-33: 111: 60.23		S10A3_HUMAN (1-90): 6.14e-31: 106: 37.78
+	Hs
		380736 S10A1_HUMAN (2-89): 2.93e-33: 111: 60.23		S100B_HUMAN (3-93): 1.16e-30: 105: 45.06
+	Hs
		596289 FILA2_HUMAN (1-92): 4.58e-30: 112: 36.96		FILA_HUMAN (1-94): 1.05e-22: 92.6: 32.98