HitPredict

Interactor 1: HLAA (P04439)
HLA class I histocompatibility antigen, A alpha chain (Human leukocyte antigen A) (HLA-A)
Gene: HLA-A

Interactor 2: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C1-set~fn3, C1-set~Furin-like, C1-set~Recep_L_domain
Common GO terms	GO:0005886 - plasma membrane GO:0009897 - external side of plasma membrane GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 365 Hs			1 1382
+	Rn
		544828 Q31255_RAT (4-364): 1.77e-156: 445: 64.38		INSR_RAT (1-1382): 0: 1527: 94.44
+	Rn
		64757 A7LNF8_RAT (25-329): 1.07e-131: 380: 66.89		INSR_RAT (1-1382): 0: 1527: 94.44
+	Hs
		382269 HLAA_HUMAN (1-365): 1.3e-177: 499: 100.00		IGF1R_HUMAN (31-1380): 0: 1353: 56.11
+	Hs
		435507 HLAC_HUMAN (1-364): 2.2e-150: 430: 80.27		IGF1R_HUMAN (31-1380): 0: 1353: 56.11
+	Hs
		533134 HLAE_HUMAN (20-357): 5.1e-143: 411: 78.99		EPHB4_HUMAN (622-1318): 2.16e-162: 515: 21.52
+	Hs
		382560 HLAA_HUMAN (1-365): 1.3e-177: 499: 100.00		ALK_HUMAN (982-1339): 1.96e-70: 263: 40.53
+	Hs
		382259 HLAA_HUMAN (1-365): 1.3e-177: 499: 100.00		NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62
+	Hs
		382433 HLAA_HUMAN (1-365): 1.3e-177: 499: 100.00		NTRK3_HUMAN (996-1290): 1.93e-64: 238: 39.43
+	Hs
		169158 HLAB_HUMAN (1-362): 3.05e-157: 447: 85.64		MUSK_HUMAN (1017-1291): 1.24e-69: 254: 42.22
+	Hs
		169162 HLAC_HUMAN (1-364): 2.2e-150: 430: 80.27		MUSK_HUMAN (1017-1291): 1.24e-69: 254: 42.22
+	Hs
		488237 HLAC_HUMAN (1-364): 2.2e-150: 430: 80.27		NTRK3_HUMAN (996-1290): 1.93e-64: 238: 39.43
+	Hs
		673955 HLAF_HUMAN (4-348): 3.64e-141: 406: 80.29		NTRK3_HUMAN (996-1290): 1.93e-64: 238: 39.43
+	Hs
		382307 HLAA_HUMAN (1-365): 1.3e-177: 499: 100.00		ERBB3_HUMAN (33-369): 1.76e-27: 123: 20.11
+	Hs
		488123 HLAC_HUMAN (1-364): 2.2e-150: 430: 80.27		ERBB3_HUMAN (33-369): 1.76e-27: 123: 20.11