HitPredict

Interactor 1: HLAA (P04439)
HLA class I histocompatibility antigen, A alpha chain (Human leukocyte antigen A) (HLA-A)
Gene: HLA-A

Interactor 2: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.798

Property	Details
Experiments	32707033, 35384245
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C1-set~ig, C1-set~LRR_8, MHC_I~ig
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 365 Hs			1 839
+	Hs
		488237 HLAC_HUMAN (1-364): 2.2e-150: 430: 80.27		NTRK3_HUMAN (1-839): 0: 671: 100.00
+	Hs
		673955 HLAF_HUMAN (4-348): 3.64e-141: 406: 80.29		NTRK3_HUMAN (1-839): 0: 671: 100.00
+	Hs
		382259 HLAA_HUMAN (1-365): 1.3e-177: 499: 100.00		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		382306 HLAA_HUMAN (1-365): 1.3e-177: 499: 100.00		FGFR2_HUMAN (203-838): 1.97e-168: 510: 24.89
+	Hs
		382280 HLAA_HUMAN (1-365): 1.3e-177: 499: 100.00		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		382308 HLAA_HUMAN (1-365): 1.3e-177: 499: 100.00		FGFR4_HUMAN (166-837): 6.43e-152: 466: 24.57
+	Hs
		382268 HLAA_HUMAN (1-365): 1.3e-177: 499: 100.00		RET_HUMAN (282-837): 1.5e-108: 360: 25.76
+	Hs
		382440 HLAA_HUMAN (1-365): 1.3e-177: 499: 100.00		DDR2_HUMAN (527-824): 2.05e-70: 250: 43.30
+	Hs
		382393 HLAA_HUMAN (1-365): 1.3e-177: 499: 100.00		ROR1_HUMAN (509-821): 2.63e-67: 243: 40.50
+	Hs
		382263 HLAA_HUMAN (1-365): 1.3e-177: 499: 100.00		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43
+	Hs
		382269 HLAA_HUMAN (1-365): 1.3e-177: 499: 100.00		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		382560 HLAA_HUMAN (1-365): 1.3e-177: 499: 100.00		ALK_HUMAN (513-816): 2.78e-59: 222: 39.03
+	Rn
		544828 Q31255_RAT (4-364): 1.77e-156: 445: 64.38		INSR_RAT (513-824): 3.31e-62: 230: 38.80
+	Hs
		570320 HLAG_HUMAN (1-338): 2.35e-151: 431: 82.84		ROR2_HUMAN (522-828): 2.97e-67: 243: 41.56
+	Hs
		488193 HLAC_HUMAN (1-364): 2.2e-150: 430: 80.27		ROR2_HUMAN (522-828): 2.97e-67: 243: 41.56
+	Hs
		435507 HLAC_HUMAN (1-364): 2.2e-150: 430: 80.27		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		533140 HLAE_HUMAN (20-357): 5.1e-143: 411: 78.99		ROR2_HUMAN (522-828): 2.97e-67: 243: 41.56
+	Rn
		64757 A7LNF8_RAT (25-329): 1.07e-131: 380: 66.89		INSR_RAT (513-824): 3.31e-62: 230: 38.80
+	Hs
		169158 HLAB_HUMAN (1-362): 3.05e-157: 447: 85.64		MUSK_HUMAN (209-391): 1.75e-22: 105: 24.60
+	Hs
		169162 HLAC_HUMAN (1-364): 2.2e-150: 430: 80.27		MUSK_HUMAN (209-391): 1.75e-22: 105: 24.60