HitPredict

Interactor 1: HLAA (P04439)
HLA class I histocompatibility antigen, A alpha chain (Human leukocyte antigen A) (HLA-A)
Gene: HLA-A

Interactor 2: CLC4E (Q9ULY5)
C-type lectin domain family 4 member E (C-type lectin superfamily member 9) (Macrophage-inducible C-type lectin) (MINCLE)
Gene: CLEC4E

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	34709727
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1-set~Lectin_C, Lectin_C~MHC_I
Common GO terms	GO:0005886 - plasma membrane GO:0009897 - external side of plasma membrane GO:0016020 - membrane GO:0030670 - phagocytic vesicle membrane GO:0045087 - innate immune response
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 365 Hs			1 219
+	Hs
		382490 HLAA_HUMAN (1-365): 1.3e-177: 499: 100.00		CLC4D_HUMAN (7-208): 1.74e-60: 190: 36.84
+	Hs
		354602 HLAB_HUMAN (1-362): 3.05e-157: 447: 85.64		CLC4E_HUMAN (1-219): 8.98e-76: 229: 100.00
+	Hs
		382561 HLAA_HUMAN (1-365): 1.3e-177: 499: 100.00		CLC4A_HUMAN (38-211): 9.75e-49: 161: 37.64
+	Hs
		488420 HLAC_HUMAN (1-364): 2.2e-150: 430: 80.27		CLC4E_HUMAN (1-219): 8.98e-76: 229: 100.00
+	Hs
		674000 HLAF_HUMAN (4-348): 3.64e-141: 406: 80.29		CLC4E_HUMAN (1-219): 8.98e-76: 229: 100.00
+	Hs
		488317 HLAC_HUMAN (1-364): 2.2e-150: 430: 80.27		CLC4D_HUMAN (7-208): 1.74e-60: 190: 36.84
+	Hs
		488421 HLAC_HUMAN (1-364): 2.2e-150: 430: 80.27		CLC4A_HUMAN (38-211): 9.75e-49: 161: 37.64
+	Hs
		674001 HLAF_HUMAN (4-348): 3.64e-141: 406: 80.29		CLC4A_HUMAN (38-211): 9.75e-49: 161: 37.64
+	Hs
		1278673 HMR1_HUMAN (1-348): 1.11e-111: 330: 36.29		CLC4E_HUMAN (1-219): 8.98e-76: 229: 100.00
+	Hs
		488269 HLAC_HUMAN (1-364): 2.2e-150: 430: 80.27		CLC4G_HUMAN (61-207): 1.57e-35: 128: 33.78
+	Hs
		673960 HLAF_HUMAN (4-348): 3.64e-141: 406: 80.29		CL12B_HUMAN (55-207): 2.11e-34: 125: 29.68
+	Hs
		570381 HLAG_HUMAN (1-338): 2.35e-151: 431: 82.84		MRC2_HUMAN (92-215): 1.99e-12: 67.8: 19.05
+	Hs
		673995 HLAF_HUMAN (4-348): 3.64e-141: 406: 80.29		CLC2D_HUMAN (67-169): 2.71e-11: 62: 35.24