HitPredict

Interactor 1: HLAA (P04439)
HLA class I histocompatibility antigen, A alpha chain (Human leukocyte antigen A) (HLA-A)
Gene: HLA-A

Interactor 2: CLC4A (Q9UMR7)
C-type lectin domain family 4 member A (C-type lectin DDB27) (C-type lectin superfamily member 6) (Dendritic cell immunoreceptor) (Lectin-like immunoreceptor) (CD antigen CD367)
Gene: CLEC4A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	33961781
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	C1-set~Lectin_C, Lectin_C~MHC_I
Common GO terms	GO:0005886 - plasma membrane GO:0009897 - external side of plasma membrane GO:0036037 - CD8-positive, alpha-beta T cell activation GO:0042590 - antigen processing and presentation of exogenous peptide antigen via MHC class I
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 365 Hs			1 237
+	Hs
		382559 HLAA_HUMAN (1-365): 1.3e-177: 499: 100.00		CLC4E_HUMAN (25-236): 9.51e-58: 184: 34.58
+	Hs
		382490 HLAA_HUMAN (1-365): 1.3e-177: 499: 100.00		CLC4D_HUMAN (31-237): 3.03e-54: 175: 33.33
+	Hs
		488421 HLAC_HUMAN (1-364): 2.2e-150: 430: 80.27		CLC4A_HUMAN (1-237): 9.8e-70: 215: 100.00
+	Hs
		354602 HLAB_HUMAN (1-362): 3.05e-157: 447: 85.64		CLC4E_HUMAN (25-236): 9.51e-58: 184: 34.58
+	Hs
		674001 HLAF_HUMAN (4-348): 3.64e-141: 406: 80.29		CLC4A_HUMAN (1-237): 9.8e-70: 215: 100.00
+	Hs
		488420 HLAC_HUMAN (1-364): 2.2e-150: 430: 80.27		CLC4E_HUMAN (25-236): 9.51e-58: 184: 34.58
+	Hs
		488317 HLAC_HUMAN (1-364): 2.2e-150: 430: 80.27		CLC4D_HUMAN (31-237): 3.03e-54: 175: 33.33
+	Hs
		674000 HLAF_HUMAN (4-348): 3.64e-141: 406: 80.29		CLC4E_HUMAN (25-236): 9.51e-58: 184: 34.58
+	Hs
		354302 HLAB_HUMAN (1-362): 3.05e-157: 447: 85.64		NKG2A_HUMAN (2-233): 1.65e-40: 140: 16.81
+	Hs
		570305 HLAG_HUMAN (1-338): 2.35e-151: 431: 82.84		NKG2A_HUMAN (2-233): 1.65e-40: 140: 16.81
+	Hs
		488269 HLAC_HUMAN (1-364): 2.2e-150: 430: 80.27		CLC4G_HUMAN (70-232): 1.34e-39: 139: 27.22
+	Hs
		673960 HLAF_HUMAN (4-348): 3.64e-141: 406: 80.29		CL12B_HUMAN (1-232): 5.06e-45: 153: 17.82
+	Hs
		533125 HLAE_HUMAN (20-357): 5.1e-143: 411: 78.99		NKG2C_HUMAN (2-233): 4.28e-41: 142: 16.81
+	Hs
		533124 HLAE_HUMAN (20-357): 5.1e-143: 411: 78.99		NKG2A_HUMAN (2-233): 1.65e-40: 140: 16.81
+	Hs
		1278673 HMR1_HUMAN (1-348): 1.11e-111: 330: 36.29		CLC4E_HUMAN (25-236): 9.51e-58: 184: 34.58
+	Hs
		570381 HLAG_HUMAN (1-338): 2.35e-151: 431: 82.84		MRC2_HUMAN (118-230): 4.47e-11: 64: 22.61
+	Hs
		644688 HMR1_HUMAN (1-348): 1.11e-111: 330: 36.29		NKG2C_HUMAN (2-233): 4.28e-41: 142: 16.81
+	Hs
		644616 HMR1_HUMAN (1-348): 1.11e-111: 330: 36.29		NKG2A_HUMAN (2-233): 1.65e-40: 140: 16.81