HitPredict

Interactor 1: HLAA (P04439)
HLA class I histocompatibility antigen, A alpha chain (Human leukocyte antigen A) (HLA-A)
Gene: HLA-A

Interactor 2: ITM2B (Q9Y287)
Integral membrane protein 2B (Immature BRI2) (imBRI2) (Protein E25B) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)]
Gene: ITM2B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	26186194, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane GO:0005615 - extracellular space GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane GO:0016020 - membrane and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 365 Hs			1 266
+	Hs
		354611 HLAB_HUMAN (1-362): 3.05e-157: 447: 85.64		ITM2B_HUMAN (1-266): 1.45e-148: 417: 100.00
+	Hs
		488426 HLAC_HUMAN (1-364): 2.2e-150: 430: 80.27		ITM2B_HUMAN (1-266): 1.45e-148: 417: 100.00
+	Hs
		488392 HLAC_HUMAN (1-364): 2.2e-150: 430: 80.27		ITM2C_HUMAN (1-265): 2.84e-120: 345: 43.12
+	Hs
		673989 HLAF_HUMAN (4-348): 3.64e-141: 406: 80.29		ITM2C_HUMAN (1-265): 2.84e-120: 345: 43.12
+	Hs
		1278675 HMR1_HUMAN (1-348): 1.11e-111: 330: 36.29		ITM2B_HUMAN (1-266): 1.45e-148: 417: 100.00