HitPredict

Interactor 1: CDK1 (P04551)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (Cell division control protein 2) (Cell division protein kinase 1) (p34 protein kinase)
Gene: cdc2

Interactor 2: CKS1 (P08463)
Cyclin-dependent kinases regulatory subunit (P13)
Gene: suc1

Species: Schizosaccharomyces pombe 972h-

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.914

Property	Details
Experiments	26771498, 9790601, 3322810, 3297353, 2569363
Identification Methods	two hybrid, protein complementation assay, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	CKS~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 297 Sp			1 113
+	Hs
		625283 CDK2_HUMAN (1-295): 2.31e-156: 439: 65.42		CKS1_HUMAN (24-101): 4.43e-34: 114: 50.00
+	Hs
		625164 CDK2_HUMAN (1-295): 2.31e-156: 439: 65.42		CKS2_HUMAN (24-106): 7.14e-32: 109: 48.19
+	Sc
		339429 CDK1_YEAST (1-295): 2.97e-130: 373: 62.88		CKS1_YEAST (8-107): 1.5e-52: 163: 73.00
+	Hs
		895413 CDK3_HUMAN (1-294): 1.16e-148: 420: 63.61		CKS1_HUMAN (24-101): 4.43e-34: 114: 50.00
+	At
		621728 CDKA1_ARATH (1-296): 8.16e-141: 400: 62.29		CKS2_ARATH (22-110): 3.09e-41: 132: 46.07
+	Hs
		706796 CDK3_HUMAN (1-294): 1.16e-148: 420: 63.61		CKS2_HUMAN (24-106): 7.14e-32: 109: 48.19
+	At
		188136 CDKA1_ARATH (1-296): 8.16e-141: 400: 62.29		CKS1_ARATH (22-101): 1.68e-37: 123: 47.50
+	Hs
		414843 CDK1_HUMAN (1-296): 8.91e-142: 402: 63.85		CKS1_HUMAN (24-101): 4.43e-34: 114: 50.00
+	Dm
		618415 CDK1_DROME (1-297): 1.88e-137: 392: 60.61		Q9VHN1_DROME (23-101): 2.81e-37: 122: 46.84
+	At
		1103378 CKB12_ARATH (1-296): 2.06e-132: 379: 55.48		CKS2_ARATH (22-110): 3.09e-41: 132: 46.07
+	Hs
		414778 CDK1_HUMAN (1-296): 8.91e-142: 402: 63.85		CKS2_HUMAN (24-106): 7.14e-32: 109: 48.19
+	Dm
		618387 CDK1_DROME (1-297): 1.88e-137: 392: 60.61		CKS1_DROME (24-101): 1.34e-34: 115: 46.15
+	At
		1227962 CKB21_ARATH (1-296): 3.31e-129: 371: 50.00		CKS2_ARATH (22-110): 3.09e-41: 132: 46.07
+	At
		1321299 CDKD1_ARATH (2-294): 1.24e-127: 370: 43.35		CKS2_ARATH (22-110): 3.09e-41: 132: 46.07
+	At
		188147 CKB12_ARATH (1-296): 2.06e-132: 379: 55.48		CKS1_ARATH (22-101): 1.68e-37: 123: 47.50
+	Hs
		895414 CDK5_HUMAN (1-296): 3.2e-136: 388: 53.20		CKS1_HUMAN (24-101): 4.43e-34: 114: 50.00
+	Hs
		706797 CDK5_HUMAN (1-296): 3.2e-136: 388: 53.20		CKS2_HUMAN (24-106): 7.14e-32: 109: 48.19
+	Dm
		618471 CDK2_DROME (1-297): 2.9e-130: 374: 56.57		Q9VHN1_DROME (23-101): 2.81e-37: 122: 46.84
+	At
		188156 CKB21_ARATH (1-296): 3.31e-129: 371: 50.00		CKS1_ARATH (22-101): 1.68e-37: 123: 47.50
+	Dm
		618437 CDK2_DROME (1-297): 2.9e-130: 374: 56.57		CKS1_DROME (24-101): 1.34e-34: 115: 46.15