HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: CADH1 (P12830)
Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]
Gene: CDH1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	25468996, 7999105
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 882
+	Cl
		94520 ERBB2_CANLF (1-1255): 0: 1278: 92.22		CADH1_CANLF (1-882): 0: 804: 81.74
+	Hs
		383600 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		CADH2_HUMAN (28-881): 0: 769: 45.86
+	Hs
		337849 EGFR_HUMAN (16-1253): 0: 1070: 48.40		CADH1_HUMAN (1-882): 0: 836: 100.00
+	Hs
		521720 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		CADH1_HUMAN (1-882): 0: 836: 100.00
+	Hs
		337911 EGFR_HUMAN (16-1253): 0: 1070: 48.40		CADH2_HUMAN (28-881): 0: 769: 45.86
+	Hs
		338302 EGFR_HUMAN (16-1253): 0: 1070: 48.40		DSC2_HUMAN (33-874): 0: 652: 27.88
+	Hs
		339197 EGFR_HUMAN (16-1253): 0: 1070: 48.40		PCDBB_HUMAN (432-868): 1.56e-70: 251: 15.28
+	Hs
		338014 EGFR_HUMAN (16-1253): 0: 1070: 48.40		CADH5_HUMAN (30-511): 8.2e-52: 196: 20.91
+	Xl
		292720 Q153D8_XENLA (1-1252): 0: 1050: 57.22		O93264_XENLA (1-365): 8.29e-49: 187: 18.47
+	Hs
		521744 EPHA2_HUMAN (671-1023): 4.87e-117: 390: 33.06		CADH1_HUMAN (1-882): 0: 836: 100.00
+	Hs
		434134 RET_HUMAN (426-1088): 3.53e-131: 432: 23.33		CADH2_HUMAN (28-881): 0: 769: 45.86
+	Hs
		580236 EPHA7_HUMAN (664-1030): 1.55e-121: 403: 30.61		CADH2_HUMAN (28-881): 0: 769: 45.86
+	Hs
		580213 EPHA4_HUMAN (668-1030): 3.69e-121: 401: 31.45		CADH2_HUMAN (28-881): 0: 769: 45.86
+	Hs
		339196 EGFR_HUMAN (16-1253): 0: 1070: 48.40		PCDB3_HUMAN (596-858): 7.97e-16: 84.2: 13.87
+	Hs
		971014 EPHA7_HUMAN (664-1030): 1.55e-121: 403: 30.61		DSC2_HUMAN (33-874): 0: 652: 27.88
+	Hs
		872632 EPHA4_HUMAN (668-1030): 3.69e-121: 401: 31.45		DSC2_HUMAN (33-874): 0: 652: 27.88
+	Hs
		665215 EPHA2_HUMAN (671-1023): 4.87e-117: 390: 33.06		DSC2_HUMAN (33-874): 0: 652: 27.88
+	Hs
		411386 INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19		DSC3_HUMAN (2-874): 0: 655: 27.92
+	Hs
		872427 EPHA5_HUMAN (707-1010): 2.37e-53: 206: 37.46		DSC2_HUMAN (33-874): 0: 652: 27.88
+	Hs
		434321 RET_HUMAN (426-1088): 3.53e-131: 432: 23.33		PCDGH_HUMAN (383-860): 1.9e-69: 249: 16.27