HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: PLAK (P14923)
Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)
Gene: JUP

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	7702605, 7999105
Identification Methods	far western blotting, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 745
+	Hs
		383648 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38
+	Hs
		337866 EGFR_HUMAN (16-1253): 0: 1070: 48.40		PLAK_HUMAN (1-745): 0: 551: 100.00
+	Hs
		542184 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		PLAK_HUMAN (1-745): 0: 551: 100.00
+	Hs
		338023 EGFR_HUMAN (16-1253): 0: 1070: 48.40		CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38
+	Hs
		239012 EGFR_HUMAN (16-1253): 0: 1070: 48.40		CTND1_HUMAN (203-728): 3.14e-90: 305: 16.25
+	Hs
		338162 EGFR_HUMAN (16-1253): 0: 1070: 48.40		IMA5_HUMAN (231-685): 6.58e-61: 215: 15.06
+	Hs
		338662 EGFR_HUMAN (16-1253): 0: 1070: 48.40		ARMC8_HUMAN (135-530): 3.88e-16: 84.5: 19.12
+	Hs
		542198 EPHB2_HUMAN (650-1103): 2.29e-122: 406: 29.47		PLAK_HUMAN (1-745): 0: 551: 100.00
+	Hs
		542333 EPHA7_HUMAN (664-1030): 1.55e-121: 403: 30.61		PLAK_HUMAN (1-745): 0: 551: 100.00
+	Hs
		542244 EPHA4_HUMAN (668-1030): 3.69e-121: 401: 31.45		PLAK_HUMAN (1-745): 0: 551: 100.00
+	Hs
		434143 RET_HUMAN (426-1088): 3.53e-131: 432: 23.33		CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38
+	Hs
		665553 EPHB2_HUMAN (650-1103): 2.29e-122: 406: 29.47		CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38
+	Hs
		717105 EPHA7_HUMAN (664-1030): 1.55e-121: 403: 30.61		CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38
+	Hs
		665156 EPHA2_HUMAN (671-1023): 4.87e-117: 390: 33.06		CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38
+	Dm
		382201 EGFR_DROME (505-1188): 2.7e-110: 380: 33.53		ARM_DROME (2-730): 6.94e-161: 488: 60.33
+	Hs
		542243 EPHA5_HUMAN (707-1010): 2.37e-53: 206: 37.46		PLAK_HUMAN (1-745): 0: 551: 100.00
+	Hs
		239027 RET_HUMAN (426-1088): 3.53e-131: 432: 23.33		CTND1_HUMAN (203-728): 3.14e-90: 305: 16.25
+	Hs
		239138 EPHA7_HUMAN (664-1030): 1.55e-121: 403: 30.61		CTND1_HUMAN (203-728): 3.14e-90: 305: 16.25
+	Hs
		239093 EPHA4_HUMAN (668-1030): 3.69e-121: 401: 31.45		CTND1_HUMAN (203-728): 3.14e-90: 305: 16.25
+	Hs
		131383 EPHA2_HUMAN (671-1023): 4.87e-117: 390: 33.06		IMA4_HUMAN (228-670): 5.34e-64: 224: 15.79