HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: FGFR4 (P22455)
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)
Gene: FGFR4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	30898150, 28205554
Identification Methods	protein complementation assay, fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation GO:0018108 - peptidyl-tyrosine phosphorylation GO:0043235 - receptor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 802
+	Hs
		383605 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGFR2_HUMAN (4-797): 0: 737: 56.44
+	Hs
		383608 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGFR3_HUMAN (5-799): 0: 712: 61.07
+	Hs
		383562 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGFR1_HUMAN (3-794): 0: 706: 54.76
+	Hs
		383631 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHA3_HUMAN (4-778): 0: 595: 18.34
+	Hs
		383712 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHA4_HUMAN (4-776): 0: 582: 19.47
+	Hs
		383710 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHA5_HUMAN (4-771): 0: 580: 18.81
+	Hs
		383711 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHB1_HUMAN (4-778): 0: 575: 17.73
+	Hs
		383630 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHA2_HUMAN (4-789): 0: 573: 19.58
+	Hs
		383632 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHB2_HUMAN (4-779): 0: 557: 17.27
+	Hs
		383709 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHB3_HUMAN (4-778): 2.87e-175: 532: 17.83
+	Hs
		383833 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		NTRK2_HUMAN (114-757): 9.58e-166: 502: 25.84
+	Hs
		383831 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		NTRK3_HUMAN (159-751): 2.33e-165: 501: 25.24
+	Hs
		383519 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		NTRK1_HUMAN (135-751): 4.91e-162: 491: 26.53
+	Hs
		383540 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		RET_HUMAN (221-802): 2.33e-148: 465: 34.72
+	Hs
		383752 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		TIE2_HUMAN (25-749): 5.61e-148: 464: 24.97
+	Hs
		1070970 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		NTRK2_HUMAN (114-757): 9.58e-166: 502: 25.84
+	Hs
		337749 EGFR_HUMAN (16-1253): 0: 1070: 48.40		NTRK1_HUMAN (135-751): 4.91e-162: 491: 26.53
+	Hs
		383779 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTK7_HUMAN (153-424): 7.29e-20: 97.1: 16.36
+	Hs
		383654 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		VGFR3_HUMAN (153-356): 9.15e-11: 67.8: 18.78
+	Hs
		383769 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		MERTK_HUMAN (123-378): 2.1e-09: 63.2: 14.66