HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: COF1 (P23528)
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)
Gene: CFL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.743

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Cofilin_ADF~PK_Tyr_Ser-Thr
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016020 - membrane GO:0032587 - ruffle membrane GO:0043066 - negative regulation of apoptotic process
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1255 Hs			1 166
+	Hs
		618088 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		COF1_HUMAN (1-166): 4.46e-72: 215: 100.00
+	Hs
		337944 EGFR_HUMAN (16-1253): 0: 1070: 48.40		COF1_HUMAN (1-166): 4.46e-72: 215: 100.00
+	Hs
		601809 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		COF1_HUMAN (1-166): 4.46e-72: 215: 100.00
+	Hs
		338343 EGFR_HUMAN (16-1253): 0: 1070: 48.40		TWF1_HUMAN (3-157): 1.01e-34: 126: 21.52