HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: 1433T (P27348)
14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1)
Gene: YWHAQ

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	24189400
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 245
+	Hs
		383724 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		383732 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		383641 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		909589 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		338232 EGFR_HUMAN (16-1253): 0: 1070: 48.40		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		337969 EGFR_HUMAN (16-1253): 0: 1070: 48.40		1433T_HUMAN (1-245): 9.47e-142: 398: 100.00
+	Hs
		338257 EGFR_HUMAN (16-1253): 0: 1070: 48.40		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		338008 EGFR_HUMAN (16-1253): 0: 1070: 48.40		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		601877 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		1433Z_HUMAN (1-245): 1.75e-141: 397: 79.59
+	Hs
		684051 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		338009 EGFR_HUMAN (16-1253): 0: 1070: 48.40		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		238393 JAK2_HUMAN (216-982): 5.65e-134: 440: 19.75		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	At
		1277300 SERK1_ARATH (420-1027): 2.94e-140: 441: 17.08		14337_ARATH (2-243): 2.78e-142: 400: 60.32
+	Hs
		169169 MUSK_HUMAN (486-984): 6.15e-120: 395: 25.14		1433E_HUMAN (2-243): 1.31e-144: 406: 63.53
+	Hs
		411315 INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19		1433B_HUMAN (1-242): 5.01e-139: 391: 81.82
+	Hs
		238392 JAK2_HUMAN (216-982): 5.65e-134: 440: 19.75		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33
+	Hs
		169164 MUSK_HUMAN (486-984): 6.15e-120: 395: 25.14		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		411316 INSR_HUMAN (584-1066): 2.91e-107: 371: 23.19		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		684033 FAK2_HUMAN (724-977): 3.75e-53: 205: 39.76		1433S_HUMAN (1-236): 9.86e-108: 312: 71.85
+	Hs
		904472 FAK1_HUMAN (706-984): 1.9e-53: 206: 39.07		1433G_HUMAN (1-242): 5.48e-105: 305: 70.33