HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: S10AB (P31949)
Protein S100-A11 (Calgizzarin) (Metastatic lymph node gene 70 protein) (MLN 70) (Protein S100-C) (S100 calcium-binding protein A11) [Cleaved into: Protein S100-A11, N-terminally processed]
Gene: S100A11

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.576

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0007165 - signal transduction
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1255 Hs			1 105
+	Hs
		383930 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		S10AG_HUMAN (8-101): 4.75e-27: 97.3: 25.26
+	Hs
		383989 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		S10AE_HUMAN (8-89): 2.78e-22: 85: 28.05
+	Hs
		685170 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		S10AB_HUMAN (1-105): 1.4e-46: 146: 100.00
+	Hs
		893799 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		S10AA_HUMAN (7-104): 1.06e-37: 123: 36.74
+	Hs
		338011 EGFR_HUMAN (16-1253): 0: 1070: 48.40		S10AB_HUMAN (1-105): 1.4e-46: 146: 100.00
+	Hs
		642945 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		S10A4_HUMAN (9-103): 6.62e-35: 116: 28.42
+	Hs
		338660 EGFR_HUMAN (16-1253): 0: 1070: 48.40		HORN_HUMAN (9-104): 4.97e-34: 125: 27.00
+	Hs
		338220 EGFR_HUMAN (16-1253): 0: 1070: 48.40		S10AA_HUMAN (7-104): 1.06e-37: 123: 36.74
+	Hs
		337962 EGFR_HUMAN (16-1253): 0: 1070: 48.40		S10A4_HUMAN (9-103): 6.62e-35: 116: 28.42
+	Hs
		337773 EGFR_HUMAN (16-1253): 0: 1070: 48.40		S10A9_HUMAN (8-98): 4.61e-33: 112: 35.87
+	Hs
		601869 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		S10AA_HUMAN (7-104): 1.06e-37: 123: 36.74
+	Hs
		338001 EGFR_HUMAN (16-1253): 0: 1070: 48.40		S10A7_HUMAN (6-100): 2.65e-24: 90: 32.99
+	Hs
		601812 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		S10A4_HUMAN (9-103): 6.62e-35: 116: 28.42
+	Hs
		380734 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		S100B_HUMAN (8-95): 7.04e-33: 111: 36.36
+	Hs
		416337 RET_HUMAN (426-1088): 3.53e-131: 432: 23.33		S10A9_HUMAN (8-98): 4.61e-33: 112: 35.87
+	Hs
		616818 JAK1_HUMAN (674-1035): 3.11e-43: 174: 21.47		FILA2_HUMAN (8-103): 1.76e-29: 112: 40.00
+	Hs
		380737 JAK1_HUMAN (674-1035): 3.11e-43: 174: 21.47		S100B_HUMAN (8-95): 7.04e-33: 111: 36.36
+	Hs
		396674 INSRR_HUMAN (359-644): 8.09e-16: 85.2: 19.27		S10A8_HUMAN (8-102): 9.02e-30: 103: 26.32