HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: IL6RB (P40189)
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Gene: IL6ST

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	11821958
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Furin-like~fn3, PK_Tyr_Ser-Thr~fn3, Recep_L_domain~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation GO:0015026 - coreceptor activity GO:0016020 - membrane GO:0043066 - negative regulation of apoptotic process and 1 others more... GO:0043235 - receptor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 918
+	Hs
		338057 EGFR_HUMAN (16-1253): 0: 1070: 48.40		IL6RB_HUMAN (1-918): 0: 623: 100.00
+	Hs
		601828 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		IL6RB_HUMAN (1-918): 0: 623: 100.00
+	Hs
		383948 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		OSMR_HUMAN (30-841): 8.5e-104: 347: 19.17
+	Mm
		250890 EGFR_MOUSE (17-1254): 0: 1126: 48.48		OSMR_MOUSE (21-838): 1.93e-93: 318: 18.29
+	Hs
		383893 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		IGDC4_HUMAN (31-624): 7.97e-36: 149: 11.59
+	Hs
		338888 EGFR_HUMAN (16-1253): 0: 1070: 48.40		OSMR_HUMAN (30-841): 8.5e-104: 347: 19.17
+	Hs
		383644 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		L1CAM_HUMAN (121-918): 4.49e-22: 105: 10.00
+	Rn
		984693 Q8K3F9_RAT (1-1255): 0: 1275: 87.98		L1CAM_RAT (121-918): 1.98e-21: 102: 10.35
+	Hs
		337831 EGFR_HUMAN (16-1253): 0: 1070: 48.40		PTPRF_HUMAN (32-733): 1.82e-83: 296: 14.38
+	Hs
		337941 EGFR_HUMAN (16-1253): 0: 1070: 48.40		PTPRD_HUMAN (1-897): 2.19e-59: 223: 11.86
+	Hs
		338085 EGFR_HUMAN (16-1253): 0: 1070: 48.40		LIFR_HUMAN (127-619): 3.5e-24: 111: 13.30
+	Hs
		338012 EGFR_HUMAN (16-1253): 0: 1070: 48.40		L1CAM_HUMAN (121-918): 4.49e-22: 105: 10.00
+	Hs
		601825 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		L1CAM_HUMAN (121-918): 4.49e-22: 105: 10.00
+	Rn
		984692 ERBB3_RAT (2-1254): 0: 1040: 38.18		L1CAM_RAT (121-918): 1.98e-21: 102: 10.35
+	Hs
		338769 EGFR_HUMAN (16-1253): 0: 1070: 48.40		TITIN_HUMAN (16-496): 1.42e-10: 67.7: 8.82
+	Mm
		960491 JAK2_MOUSE (216-982): 1.28e-136: 447: 19.53		IL6RB_MOUSE (1-918): 0: 574: 77.04
+	Mm
		956337 JAK2_MOUSE (216-982): 1.28e-136: 447: 19.53		I12R2_MOUSE (1-849): 2.67e-88: 302: 19.84
+	Mm
		995942 JAK2_MOUSE (216-982): 1.28e-136: 447: 19.53		PRLR_MOUSE (115-336): 4.67e-52: 195: 27.90
+	Hs
		238348 JAK2_HUMAN (216-982): 5.65e-134: 440: 19.75		PRLR_HUMAN (124-351): 1.32e-50: 190: 25.83
+	Mm
		817305 JAK2_MOUSE (216-982): 1.28e-136: 447: 19.53		LEPR_MOUSE (4-824): 4.33e-15: 82.3: 13.77