HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: MATK (P42679)
Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (CSK homologous kinase) (CHK) (Hematopoietic consensus tyrosine-lacking kinase) (Protein kinase HYL) (Tyrosine-protein kinase CTK)
Gene: MATK

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.857

Property	Details
Experiments	9461599, 16273093, 12122014
Identification Methods	affinity chromatography technology, pull down, unspecified method, protein array
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0004713 - protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005829 - cytosol GO:0006468 - protein phosphorylation GO:0008284 - positive regulation of cell population proliferation and 1 others more... GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 507
+	Hs
		383529 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FYN_HUMAN (28-493): 0: 527: 32.23
+	Hs
		383538 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		YES_HUMAN (4-493): 0: 523: 31.94
+	Hs
		383570 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SRC_HUMAN (30-493): 0: 523: 34.52
+	Hs
		383551 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGR_HUMAN (4-494): 0: 519: 32.03
+	Hs
		383528 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LCK_HUMAN (39-492): 1.32e-180: 518: 34.62
+	Rn
		1225226 Q8K3F9_RAT (1-1255): 0: 1275: 87.98		SRC_RAT (30-493): 0: 519: 34.52
+	Hs
		383547 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		HCK_HUMAN (26-490): 3.62e-178: 512: 33.47
+	Hs
		337300 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ABL1_HUMAN (26-486): 1.44e-165: 499: 32.70
+	Hs
		383665 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		CSK_HUMAN (45-485): 8.23e-174: 498: 53.05
+	Hs
		383673 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ABL2_HUMAN (13-503): 2.01e-164: 498: 31.37
+	Hs
		383539 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LYN_HUMAN (14-490): 4.73e-171: 493: 31.73
+	Hs
		383767 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ITK_HUMAN (33-484): 4.01e-169: 493: 33.12
+	Hs
		383699 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		BLK_HUMAN (10-492): 2.69e-169: 489: 32.66
+	Hs
		383672 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		TXK_HUMAN (1-484): 1.5e-154: 452: 29.47
+	Hs
		383671 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		TEC_HUMAN (16-490): 3.23e-152: 450: 29.41
+	Mm
		403432 EGFR_MOUSE (17-1254): 0: 1126: 48.48		SRC_MOUSE (14-493): 0: 523: 34.07
+	Rn
		1351588 Q9QX70_RAT (21-1254): 0: 1116: 48.96		SRC_RAT (30-493): 0: 519: 34.52
+	Hs
		337480 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		ABL1_HUMAN (26-486): 1.44e-165: 499: 32.70
+	Hs
		383589 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FER_HUMAN (75-478): 2.04e-80: 268: 38.86
+	Hs
		383794 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTK6_HUMAN (66-479): 8.11e-80: 258: 38.73