HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: EPHB1 (P54762)
Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2)
Gene: EPHB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	30898150
Identification Methods	protein complementation assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Furin-like~fn3, EphA2_TM~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SAM_1, Recep_L_domain~fn3
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0022008 - neurogenesis GO:0070372 - regulation of ERK1 and ERK2 cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 984
+	Hs
		383632 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHB2_HUMAN (19-981): 0: 1198: 73.76
+	Hs
		383712 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHA4_HUMAN (13-983): 0: 1150: 59.10
+	Hs
		383710 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHA5_HUMAN (1-981): 0: 1143: 55.78
+	Hs
		383631 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHA3_HUMAN (14-981): 0: 1131: 55.67
+	Hs
		383709 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHB3_HUMAN (16-979): 0: 1118: 70.56
+	Hs
		383630 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHA2_HUMAN (17-978): 0: 1032: 46.58
+	Hs
		383604 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHA1_HUMAN (11-973): 0: 955: 41.76
+	Hs
		171278 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		EPHB6_HUMAN (2-969): 0: 896: 46.49
+	Hs
		383769 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		MERTK_HUMAN (131-927): 2.42e-167: 517: 21.61
+	Hs
		383575 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		INSRR_HUMAN (278-912): 3.5e-157: 499: 25.72
+	Hs
		383763 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		TYRO3_HUMAN (131-964): 6.38e-160: 495: 19.28
+	Hs
		383527 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		INSR_HUMAN (275-940): 4.21e-150: 482: 25.81
+	Hs
		383541 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		IGF1R_HUMAN (390-883): 2.15e-141: 458: 30.71
+	Hs
		337768 EGFR_HUMAN (16-1253): 0: 1070: 48.40		INSR_HUMAN (275-940): 4.21e-150: 482: 25.81
+	Hs
		337794 EGFR_HUMAN (16-1253): 0: 1070: 48.40		IGF1R_HUMAN (390-883): 2.15e-141: 458: 30.71
+	Hs
		383547 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		HCK_HUMAN (579-879): 7.25e-65: 229: 40.07
+	Hs
		383529 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FYN_HUMAN (613-879): 2.52e-64: 228: 42.54
+	Hs
		442833 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		HCK_HUMAN (579-879): 7.25e-65: 229: 40.07
+	Hs
		412202 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		FYN_HUMAN (613-879): 2.52e-64: 228: 42.54
+	Hs
		337804 EGFR_HUMAN (16-1253): 0: 1070: 48.40		HCK_HUMAN (579-879): 7.25e-65: 229: 40.07