HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: GBRL2 (P60520)
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (General protein transport factor p16) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) (MAP1 light chain 3-related protein)
Gene: GABARAPL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.576

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1255 Hs			1 117
+	Hs
		383970 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		GBRL1_HUMAN (1-116): 7.89e-56: 170: 61.21
+	Hs
		891156 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		GBRL2_HUMAN (1-117): 1.08e-58: 178: 100.00
+	Hs
		338214 EGFR_HUMAN (16-1253): 0: 1070: 48.40		GBRL2_HUMAN (1-117): 1.08e-58: 178: 100.00
+	Hs
		601867 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		GBRL2_HUMAN (1-117): 1.08e-58: 178: 100.00
+	Hs
		338975 EGFR_HUMAN (16-1253): 0: 1070: 48.40		MLP3A_HUMAN (5-117): 2.01e-45: 144: 41.74
+	Hs
		601995 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		GBRL1_HUMAN (1-116): 7.89e-56: 170: 61.21
+	Mm
		724172 RET_MOUSE (426-1088): 1.18e-124: 414: 22.78		MLP3B_MOUSE (2-116): 2.53e-44: 141: 38.46
+	Hs
		1072594 EPHA7_HUMAN (664-1030): 1.55e-121: 403: 30.61		MLP3A_HUMAN (5-117): 2.01e-45: 144: 41.74
+	Hs
		872571 EPHB4_HUMAN (707-1000): 4.94e-53: 204: 38.21		MLP3B_HUMAN (2-117): 6.34e-44: 141: 38.14