HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.982

The method score is based on:

Property Details
Experiments 8665853, 11606575, 17875712, 16729043, 30898150, 31980649, 22973453, 9710588, 35384245, 9756944, 16273093, unassigned2173, 21278786, 24189400, 24658140
Identification Methods pull down, affinity chromatography technology, two hybrid, proximity labelling technology, unspecified method, protein array, ubiquitin reconstruction, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007165 - signal transduction
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Last updated: 15 Jul 2024