HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: XIAP (P98170)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	34591642
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	BIR~PK_Tyr_Ser-Thr
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043066 - negative regulation of apoptotic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1255 Hs			1 497
+	Hs
		338280 EGFR_HUMAN (16-1253): 0: 1070: 48.40		XIAP_HUMAN (1-497): 0: 569: 100.00
+	Hs
		338383 EGFR_HUMAN (16-1253): 0: 1070: 48.40		BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31
+	Hs
		338382 EGFR_HUMAN (16-1253): 0: 1070: 48.40		BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94
+	Hs
		338580 EGFR_HUMAN (16-1253): 0: 1070: 48.40		LRSM1_HUMAN (330-497): 2.09e-24: 108: 18.45
+	Hs
		338889 EGFR_HUMAN (16-1253): 0: 1070: 48.40		CGRF1_HUMAN (317-491): 2.2e-23: 102: 14.29
+	Hs
		957688 FAK1_HUMAN (706-984): 1.9e-53: 206: 39.07		XIAP_HUMAN (1-497): 0: 569: 100.00
+	Hs
		434233 RET_HUMAN (426-1088): 3.53e-131: 432: 23.33		MIB1_HUMAN (311-492): 5.04e-16: 83.1: 13.68
+	Hs
		665280 EPHA2_HUMAN (671-1023): 4.87e-117: 390: 33.06		MIB1_HUMAN (311-492): 5.04e-16: 83.1: 13.68