HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: PTN12 (Q05209)
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
Gene: PTPN12

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	19167335, 21376233
Identification Methods	phosphatase assay, bimolecular fluorescence complementation
Interaction Type	dephosphorylation reaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0071364 - cellular response to epidermal growth factor stimulus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 780
+	Hs
		383545 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30
+	Hs
		384039 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTN22_HUMAN (1-779): 6.27e-132: 413: 32.01
+	Hs
		383611 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRB_HUMAN (7-314): 1.22e-123: 410: 29.62
+	Hs
		383633 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25
+	Mm
		728828 EGFR_MOUSE (17-1254): 0: 1126: 48.48		PTN12_MOUSE (1-780): 0: 560: 83.10
+	Hs
		983487 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		PTN12_HUMAN (1-780): 0: 586: 100.00
+	Hs
		383762 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Hs
		383950 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTN18_HUMAN (14-446): 4.35e-123: 378: 32.66
+	Hs
		383597 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRA_HUMAN (7-295): 5.6e-105: 342: 32.08
+	Hs
		146920 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRT_HUMAN (8-296): 7.41e-63: 231: 25.93
+	Mm
		719299 EGFR_MOUSE (17-1254): 0: 1126: 48.48		PTN11_MOUSE (7-351): 2.04e-124: 387: 31.48
+	Hs
		665895 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25
+	Hs
		383818 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRK_HUMAN (17-297): 1.82e-59: 221: 26.64
+	Hs
		383910 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRU_HUMAN (7-293): 8.06e-59: 219: 21.36
+	Hs
		383612 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRG_HUMAN (8-299): 1.84e-52: 200: 24.50
+	Hs
		383836 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRO_HUMAN (58-303): 3.31e-46: 180: 38.71
+	Hs
		383771 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		PTPRJ_HUMAN (49-297): 6.23e-46: 179: 39.13
+	Hs
		146927 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		PTPRT_HUMAN (8-296): 7.41e-63: 231: 25.93
+	Hs
		719339 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		PTN7_HUMAN (58-298): 7.19e-43: 161: 38.93
+	Rn
		1143998 ERBB4_RAT (1-1237): 0: 1101: 45.47		PTPRZ_RAT (51-293): 3.21e-20: 98.6: 28.00