HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: ARHG5 (Q12774)
Rho guanine nucleotide exchange factor 5 (Ephexin-3) (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (Transforming immortalized mammary oncogene) (p60 TIM)
Gene: ARHGEF5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 1597
+	Hs
		338341 EGFR_HUMAN (16-1253): 0: 1070: 48.40		ARHG5_HUMAN (1-1597): 7.13e-161: 532: 100.00
+	Hs
		383580 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		VAV_HUMAN (1127-1525): 1.6e-84: 298: 15.92
+	Hs
		383927 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		Q96D37_HUMAN (1127-1525): 5.42e-85: 298: 15.92
+	Hs
		384022 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		VAV3_HUMAN (1127-1523): 5.41e-80: 285: 14.36
+	Hs
		383705 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		VAV2_HUMAN (1094-1525): 8.15e-78: 279: 14.58
+	Mm
		654977 EGFR_MOUSE (17-1254): 0: 1126: 48.48		VAV_MOUSE (1094-1525): 1.95e-84: 298: 14.48
+	Hs
		548711 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		VAV_HUMAN (1127-1525): 1.6e-84: 298: 15.92
+	Hs
		1071026 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		VAV3_HUMAN (1127-1523): 5.41e-80: 285: 14.36
+	Hs
		855797 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		VAV2_HUMAN (1094-1525): 8.15e-78: 279: 14.58
+	Hs
		338478 EGFR_HUMAN (16-1253): 0: 1070: 48.40		ITSN1_HUMAN (56-1523): 8.75e-83: 303: 12.75
+	Hs
		337872 EGFR_HUMAN (16-1253): 0: 1070: 48.40		VAV_HUMAN (1127-1525): 1.6e-84: 298: 15.92
+	Hs
		338823 EGFR_HUMAN (16-1253): 0: 1070: 48.40		Q96D37_HUMAN (1127-1525): 5.42e-85: 298: 15.92
+	Hs
		339058 EGFR_HUMAN (16-1253): 0: 1070: 48.40		ITSN2_HUMAN (767-1521): 1.68e-79: 293: 14.54
+	Hs
		339121 EGFR_HUMAN (16-1253): 0: 1070: 48.40		VAV3_HUMAN (1127-1523): 5.41e-80: 285: 14.36
+	Hs
		338167 EGFR_HUMAN (16-1253): 0: 1070: 48.40		VAV2_HUMAN (1094-1525): 8.15e-78: 279: 14.58
+	Hs
		548637 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		VAV_HUMAN (1127-1525): 1.6e-84: 298: 15.92
+	Hs
		601970 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		Q96D37_HUMAN (1127-1525): 5.42e-85: 298: 15.92
+	Hs
		224717 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		KALRN_HUMAN (1147-1586): 2.29e-59: 229: 16.18
+	Hs
		602023 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		VAV3_HUMAN (1127-1523): 5.41e-80: 285: 14.36
+	Hs
		601860 ERBB3_HUMAN (5-1254): 0: 1041: 38.55		VAV2_HUMAN (1094-1525): 8.15e-78: 279: 14.58