HitPredict

Interactor 1: ERBB2 (P04626)
Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto-oncogene Neu) (Proto-oncogene c-ErbB-2) (Tyrosine kinase-type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)
Gene: ERBB2

Interactor 2: SLAP1 (Q13239)
Src-like-adapter (Src-like-adapter protein 1) (SLAP-1) (hSLAP)
Gene: SLA

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	16273093
Identification Methods	unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 276
+	Hs
		383539 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LYN_HUMAN (3-275): 4.33e-95: 290: 27.68
+	Hs
		383528 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		LCK_HUMAN (2-276): 2.03e-90: 278: 29.83
+	Hs
		383529 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FYN_HUMAN (8-274): 5.24e-90: 278: 29.03
+	Hs
		383538 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		YES_HUMAN (24-275): 3.54e-89: 276: 28.52
+	Hs
		383547 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		HCK_HUMAN (3-275): 2.2e-87: 271: 27.02
+	Hs
		383570 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SRC_HUMAN (2-275): 2.76e-87: 271: 27.37
+	Hs
		383551 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		FGR_HUMAN (13-275): 3.36e-87: 270: 26.64
+	Rn
		1225226 Q8K3F9_RAT (1-1255): 0: 1275: 87.98		SRC_RAT (2-274): 1.76e-87: 272: 27.47
+	Hs
		383699 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		BLK_HUMAN (4-275): 9.14e-85: 263: 30.14
+	Hs
		337300 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ABL1_HUMAN (2-275): 1.88e-79: 261: 23.40
+	Hs
		383673 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ABL2_HUMAN (8-275): 6.54e-76: 252: 22.10
+	Hs
		383767 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		ITK_HUMAN (5-275): 1.59e-76: 245: 21.53
+	Hs
		383671 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		TEC_HUMAN (1-275): 6.36e-75: 242: 17.57
+	Hs
		383672 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		TXK_HUMAN (23-276): 4.06e-74: 237: 17.54
+	Hs
		383665 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		CSK_HUMAN (15-275): 1.13e-73: 233: 20.44
+	Hs
		383977 ERBB2_HUMAN (1-1255): 0: 1282: 100.00		SLAP2_HUMAN (12-248): 1.98e-74: 229: 40.74
+	Mm
		403432 EGFR_MOUSE (17-1254): 0: 1126: 48.48		SRC_MOUSE (2-274): 3.56e-87: 271: 27.47
+	Rn
		1351588 Q9QX70_RAT (21-1254): 0: 1116: 48.96		SRC_RAT (2-274): 1.76e-87: 272: 27.47
+	Hs
		411729 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		LCK_HUMAN (2-276): 2.03e-90: 278: 29.83
+	Hs
		337480 ERBB4_HUMAN (6-1237): 0: 1098: 45.45		ABL1_HUMAN (2-275): 1.88e-79: 261: 23.40